Document Detail


Emphysema: the challenge of the remodelled lung.
MedLine Citation:
PMID:  14743495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Emphysema is recognized as the component of chronic obstructive airways disease that is responsible for airways obstruction. Different patterns of emphysema are, however, recognized, suggesting possible different pathogenetic processes within the lung. This, coupled with the associated idea of susceptibility factors to the development of emphysema, has led to studies of genes that may be involved in the defence of the lung from proteolytic and oxidative damage. These studies have been driven by the goal of finding a treatment for emphysema, but appear to have lost sight of the fundamental remodelling of the lung that has occurred in patients with emphysema and the fact that it is not a single morphological entity.
Authors:
R Blundell; D J Harrison; W A H Wallace
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of pathology     Volume:  202     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-03-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
Copyright Information:
Copyright 2004 John Wiley & Sons, Ltd.
Affiliation:
Directorate of Pathology, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, UK.
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MeSH Terms
Descriptor/Qualifier:
Gene Therapy
Humans
Oxidative Stress
Pulmonary Emphysema / etiology*,  genetics,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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