Document Detail

Emotional stress-induced 'ampulla cardiomyopathy': discrepancy between the metabolic and sympathetic innervation imaging performed during the recovery course.
MedLine Citation:
PMID:  11316138     Owner:  NLM     Status:  MEDLINE    
Four patients had the clinical features of 'ampulla cardiomyopathy', consisting of acute-onset transient left ventricular apical akinesis with basal normokinesis, normal coronary angiogram, ST-segment elevation and subsequent giant T wave inversion, which mimicked acute coronary syndrome, the onset of which occurred shortly after extreme mental stress. Myocardial necrosis was minimal, although 2 patients showed elevated serum catecholamine levels in the acute phase. Each patient underwent serial cardiac radionuclide single-photon emission computed tomography of myocardial functional sympathetic innervation, fatty acid metabolism and perfusion using I-123-metaiodobenzyl-guanidine (MIBG), I-123-beta-metyl-iodophenyl pentadecanoic acid (BMIPP) and thallium-201 (201Tl), respectively. In the acute phase, MIBG and BMIPP imaging showed an uptake defect in the apical region, whereas 201Tl uptake was mildly decreased. When assessed semi-quantitatively, the MIBG images had higher defect scores from the acute phase throughout the year of observation compared with BMIPP, and 201Tl. These observations suggest that the primary cause of ampulla cardiomyopathy is related to a disturbance of the cardiac sympathetic innervation.
M Owa; K Aizawa; N Urasawa; H Ichinose; K Yamamoto; K Karasawa; M Kagoshima; J Koyama; S Ikeda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  65     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-23     Completed Date:  2001-09-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  349-52     Citation Subset:  IM    
Third Department of Internal Medicine, Shinshu University School of Medicine, Nagano, Japan.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use,  pharmacokinetics
Autonomic Nervous System Diseases / etiology*,  physiopathology
Catecholamines / blood
Chest Pain / etiology
Family Relations
Fatty Acids / diagnostic use,  metabolism
Heart / radionuclide imaging
Heart Conduction System / physiopathology*
Iodine Radioisotopes / diagnostic use
Iodobenzenes / diagnostic use
Middle Aged
Myocardium / metabolism
Nerve Endings / radionuclide imaging
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Stress, Psychological / complications*,  physiopathology
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon
Ventricular Dysfunction, Left / blood,  etiology*,  pathology,  radionuclide imaging
Reg. No./Substance:
0/Catecholamines; 0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 116754-87-1/iodofiltic acid; 77679-27-7/3-Iodobenzylguanidine

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