Document Detail


Emotional neglect in childhood and cerebral infarction in older age.
MedLine Citation:
PMID:  22993291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of the study was to test the hypothesis that a higher level of childhood adversity is associated with increased risk of cerebral infarction in old age.
METHODS: Older participants in a longitudinal clinical-pathologic study rated adverse childhood experiences (e.g., emotional neglect, parental intimidation and violence) on a previously established 16-item scale. During a mean of 3.5 years of follow-up, there were 257 deaths, with 206 brain autopsies (80.2). Number of chronic cerebral infarcts (gross plus microscopic; expressed as 0, 1, or >1) was determined in a uniform neuropathologic examination, which had been completed in 192 individuals at the time of these analyses.
RESULTS: Childhood adversity scores ranged from 0 to 31 (mean = 8.3, SD = 6.4). In an ordinal logistic regression model adjusted for age, sex, and education, higher adversity was associated with higher likelihood of chronic cerebral infarction. In analyses of childhood adversity subscales, only emotional neglect was associated with infarction (odds ratio [OR] = 1.097; 95% confidence interval [CI] 1.048-1.148). The likelihood of infarction was 2.8 times higher (95% CI 2.0-4.1) in those reporting a moderately high level of childhood emotional neglect (score = 6, 75th percentile) vs a moderately low level of neglect (score = 1, 25th percentile). Results were comparable in subsequent analyses that controlled for lifetime socioeconomic status, cardiovascular risk factors, and an anxiety-related trait.
CONCLUSION: Emotional neglect in childhood may be a risk factor for cerebral infarction in old age.
Authors:
Robert S Wilson; Patricia A Boyle; Steven R Levine; Lei Yu; Sophia E Anagnos; Aron S Buchman; Julie A Schneider; David A Bennett
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-19
Journal Detail:
Title:  Neurology     Volume:  79     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-01-11     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1534-9     Citation Subset:  AIM; IM    
Affiliation:
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cerebral Infarction / epidemiology*
Child
Child Abuse / psychology*
Emotions*
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Parents
Risk
Stress, Psychological / psychology*
Grant Support
ID/Acronym/Agency:
R01 AG034374/AG/NIA NIH HHS; R01AG17917/AG/NIA NIH HHS; R01AG24480/AG/NIA NIH HHS; R01AG24871/AG/NIA NIH HHS; R01AG33678/AG/NIA NIH HHS; R01AG34374/AG/NIA NIH HHS; R01HL94966/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Neurology. 2012 Oct 9;79(15):1524-5   [PMID:  22993278 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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