Document Detail


Emotion recognition impairment and apathy after subthalamic nucleus stimulation in Parkinson's disease have separate neural substrates.
MedLine Citation:
PMID:  18579165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test the hypothesis that emotion recognition and apathy share the same functional circuit involving the subthalamic nucleus (STN). METHODS: A consecutive series of 17 patients with advanced Parkinson's disease (PD) was assessed 3 months before (M-3) and 3 months (M+3) after STN deep brain stimulation (DBS). Mean (+/-S.D.) age at surgery was 56.9 (8.7) years. Mean disease duration at surgery was 11.8 (2.6) years. Apathy was measured using the Apathy Evaluation Scale (AES) at both M-3 and M3. Patients were also assessed using a computerised paradigm of facial emotion recognition [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto: Consulting Psychologist Press] before and after STN DBS. Prior to this, the Benton Facial Recognition Test was used to check that the ability to perceive faces was intact. RESULTS: Apathy had significantly worsened at M3 (42.5+/-8.9, p=0.006) after STN-DBS, in relation to the preoperative assessment (37.2+/-5.5). There was also a significant reduction in recognition percentages for facial expressions of fear (43.1%+/-22.9 vs. 61.6%+/-21.4, p=0.022) and sadness (52.7%+/-19.1 vs. 67.6%+/-22.8, p=0.031) after STN DBS. However, the postoperative worsening of apathy and emotion recognition impairment were not correlated. CONCLUSIONS: Our results confirm that the STN is involved in both the apathy and emotion recognition networks. However, the absence of any correlation between apathy and emotion recognition impairment suggests that the worsening of apathy following surgery could not be explained by a lack of facial emotion recognition and that its behavioural and cognitive components should therefore also be taken into consideration.
Authors:
D Drapier; J Péron; E Leray; P Sauleau; I Biseul; S Drapier; F Le Jeune; D Travers; A Bourguignon; C Haegelen; B Millet; M Vérin
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-05-20
Journal Detail:
Title:  Neuropsychologia     Volume:  46     ISSN:  0028-3932     ISO Abbreviation:  Neuropsychologia     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-11-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0020713     Medline TA:  Neuropsychologia     Country:  England    
Other Details:
Languages:  eng     Pagination:  2796-801     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Centre Hospitalier Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes, France. dominique.drapier@univ-rennes1.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Depression* / etiology,  pathology,  psychology
Emotions / physiology*
Facial Expression
Female
Humans
Male
Memory Disorders* / etiology,  pathology,  psychology
Middle Aged
Motor Activity
Neuropsychological Tests
Parkinson Disease / therapy
Photic Stimulation
Psychiatric Status Rating Scales
Recognition (Psychology) / physiology*
Statistics, Nonparametric
Subthalamic Nucleus / physiopathology,  radiation effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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