Document Detail


Emotion causes targeted forgetting of established memories.
MedLine Citation:
PMID:  21191439     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Reconsolidation postulates that reactivation of a memory trace renders it susceptible to disruption by treatments similar to those that impair initial memory consolidation. Despite evidence that implicit, or non-declarative, human memories can be disrupted at retrieval, a convincing demonstration of selective impairment in retrieval of target episodic memories following reactivation is lacking. In human subjects, we demonstrate that if reactivation of a verbal memory, through successful retrieval, is immediately followed by an emotionally aversive stimulus, a significant impairment is evident in its later recall. This effect is time-dependent and persists for at least 6 days. Thus, in line with a reconsolidation hypothesis, established human episodic memories can be selectively impaired following their retrieval.
Authors:
Bryan A Strange; Marijn C W Kroes; Judith E Fan; Raymond J Dolan
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Publication Detail:
Type:  Journal Article     Date:  2010-11-19
Journal Detail:
Title:  Frontiers in behavioral neuroscience     Volume:  4     ISSN:  1662-5153     ISO Abbreviation:  Front Behav Neurosci     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-30     Completed Date:  2011-07-14     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477952     Medline TA:  Front Behav Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  175     Citation Subset:  -    
Affiliation:
Wellcome Trust Centre for Neuroimaging, Institute of Neurology London, UK.
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