| Emetic activity of N-substituted norapomorphines. | |
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MedLine Citation:
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PMID: 808605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Norapomorphine and ten of its N-substituted derivatives were prepared by modifications of procedures described earlier. In a dog emesis test the N-ethyl and N-n-propyl compounds had minimum effective doses of 0.00025 and 0.0005 mg/kg, respectively, when administered iv, sc, or im. In a modified Irwin mouse profile screen the minimum effective iv dose was 0.013 mg/kg for the N-ethyl and 0.0024 mg/kg for the N-n-propyl compound; percutaneous absorption was also observed in mice. All compounds examined caused the stereotyped apomorphine behavior syndrome but hypotensive effects were not serious. |
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Authors:
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E R Atkinson; F J Bullock; F E Granchelli; S Archer; F J Rosenberg; D G Teiger; F C Nachod |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 18 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1975 Oct |
Date Detail:
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Created Date: 1975-12-05 Completed Date: 1975-12-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1000-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / analogs & derivatives*, chemical synthesis*, pharmacology Blood Pressure / drug effects Cats Depression, Chemical Dogs Emetics / chemical synthesis*, pharmacology Female Haplorhini Humans Male Mice Stereotyped Behavior / drug effects Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Emetics; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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