Document Detail

Emerging roles of fibronectin in thrombosis.
MedLine Citation:
PMID:  20116835     Owner:  NLM     Status:  MEDLINE    
Fibronectin (FN) is a glycoprotein recognized originally in the 1940's as a contaminant of fibrinogen in Cohn fraction I of plasma. Decades of research demonstrated FN synthesis by a variety of cells and defined FN as an essential component of the extracellular matrix with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. We discuss the mechanisms by which this might occur and conclude that FN may have a unique role in thrombosis without affecting normal hemostasis and therefore may be a reasonable therapeutic target for the prevention of thrombotic diseases.
Lisa M Maurer; Bianca R Tomasini-Johansson; Deane F Mosher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-02-08
Journal Detail:
Title:  Thrombosis research     Volume:  125     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-07-02     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Blood Proteins
Extracellular Matrix / genetics,  metabolism*
Fibrinogen / genetics,  metabolism
Fibronectins* / blood,  genetics,  metabolism
Morphogenesis / genetics
Thrombosis / genetics,  metabolism
Wound Healing / genetics*
Grant Support
Reg. No./Substance:
0/Blood Proteins; 0/Cohn fraction I; 0/Fibronectins; 9001-32-5/Fibrinogen

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