| Emerging roles of fibronectin in thrombosis. | |
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MedLine Citation:
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PMID: 20116835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibronectin (FN) is a glycoprotein recognized originally in the 1940's as a contaminant of fibrinogen in Cohn fraction I of plasma. Decades of research demonstrated FN synthesis by a variety of cells and defined FN as an essential component of the extracellular matrix with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. We discuss the mechanisms by which this might occur and conclude that FN may have a unique role in thrombosis without affecting normal hemostasis and therefore may be a reasonable therapeutic target for the prevention of thrombotic diseases. |
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Authors:
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Lisa M Maurer; Bianca R Tomasini-Johansson; Deane F Mosher |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-02-08 |
Journal Detail:
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Title: Thrombosis research Volume: 125 ISSN: 1879-2472 ISO Abbreviation: Thromb. Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-07-02 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: 287-91 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of Wisconsin-Madison, Madison, WI, USA. lmaurer@wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Proteins Cricetinae Extracellular Matrix / genetics, metabolism* Fibrinogen / genetics, metabolism Fibronectins* / blood, genetics, metabolism Morphogenesis / genetics Thrombosis / genetics, metabolism Wound Healing / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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HL021644/HL/NHLBI NIH HHS; R01 HL021644-31/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Cohn fraction I; 0/Fibronectins; 9001-32-5/Fibrinogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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