Document Detail

Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.
MedLine Citation:
PMID:  14528275     Owner:  NLM     Status:  MEDLINE    
The small DNA virus proteins E1A and E1B from human Adenovirus, E6 and E7 from human papillomavirus, and large T and small T antigens from SV40, are multifaceted molecular tools that can carry out an impressive number of tasks in the host cell. These viral factors, collectively termed 'oncoproteins' for their ability to induce cancer, can be viewed as paradigmatic oncogenic factors which can disrupt checkpoint controls at multiple levels--they interfere with both 'gatekeeper' cellular functions, including major control pathways of cell cycle and apoptosis, and with 'caretaker' functions, thereby inducing mitotic abnormalities and increasing genomic instability. Both E1A and E7 have been recently found to interact physically with the Ran GTPase. This interaction is key in uncoupling the centrosome cycle from the cell cycle, highlighting a direct link between viral infection and the induction of genomic instability. Further expanding our current knowledge in this field will be crucial to elucidate viral strategies leading to cellular transformation and cancer progression, as well as design novel preventive or therapeutic approaches to human cancer.
Patrizia Lavia; Anna Maria Mileo; Antonio Giordano; Marco G Paggi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Oncogene     Volume:  22     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-06     Completed Date:  2003-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  6508-16     Citation Subset:  IM    
Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
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MeSH Terms
Adenovirus E1A Proteins / genetics
Cell Division
Centrosome / ultrastructure
DNA Tumor Viruses / genetics*
Neoplasms / genetics*,  virology
Oncogene Proteins / genetics
Tumor Virus Infections / genetics*,  pathology*
ran GTP-Binding Protein / genetics
Reg. No./Substance:
0/Adenovirus E1A Proteins; 0/Oncogene Proteins; EC GTP-Binding Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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