| Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 21254858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Fatty liver disease (FLD); associated with chronic alcohol consumption or obesity, is a serious medical problem. Strong evidence indicates that oxidative stress and dysregulation of redox-sensitive signaling pathways are central to the pathobiology of FLD. Herein, this FORUM summarizes current knowledge regarding mechanisms of FLD from both clinical and experimental studies. Special emphasis is given to the role of redox biology disturbances in the initiation and progression of FLD from both chronic alcohol consumption and obesity. Focus areas in this FORUM include discussions on the: 1) multi-hit hypothesis; 2) interaction of adipokines and redox signaling pathways; 3) role of sub-cellular organelle systems (i.e., endoplasmic reticulum and mitochondria); and 3) contribution of the innate immune system, in FLD. A state-of-the-art discussion is also included highlighting key lessons learned from experimental studies using rodent models of FLD. |
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Authors:
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Ariel E Feldstein; Shannon M Bailey |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-23 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: - ISSN: 1557-7716 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Lerner Research Institute, Cleveland Clinic, Cell Biology and Pediatric Gastroenterology, 9500 Euclid avenue, Cleveland, Ohio, United States, 44195; feldsta@ccf.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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