Document Detail


Emerging role of lipid droplets in host/pathogen interactions.
MedLine Citation:
PMID:  22090026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipid droplets (LDs) are highly dynamic cell organelles involved in energy homeostasis and membrane trafficking. Here, we review how select pathogens interact with LDs. Several RNA viruses use host LDs at different steps of their life cycle. Some intracellular bacteria and parasites usurp host LDs or encode their own lipid biosynthesis machinery, thus allowing production of LDs independently of their host. Although many mechanistic details of host/pathogen LD interactions are unknown, a picture emerges in which the unique cellular architecture and energy stored in LDs are important in the replication of diverse pathogens.
Authors:
Eva Herker; Melanie Ott
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-16
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  287     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-03-15     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2280-7     Citation Subset:  IM    
Affiliation:
Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / metabolism*
Bacterial Physiological Phenomena*
Biological Transport, Active
Energy Metabolism*
Host-Pathogen Interactions / physiology*
Humans
Intracellular Membranes / metabolism
Lipid Metabolism*
RNA Viruses / physiology*
Grant Support
ID/Acronym/Agency:
P30 DK026743/DK/NIDDK NIH HHS; R56 AI085056/AI/NIAID NIH HHS
Comments/Corrections

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