Document Detail

Emerging role of angiogenin in stress response and cell survival under adverse conditions.
MedLine Citation:
PMID:  22021078     Owner:  NLM     Status:  MEDLINE    
Angiogenin (ANG), also known as ribonuclease (RNASE) 5, is a member of the vertebrate-specific, secreted RNASE superfamily. ANG was originally identified as a tumor angiogenic factor, but its biological activity has been extended from inducing angiogenesis to stimulating cell proliferation and more recently, to promoting cell survival. Under growth conditions, ANG is translocated to nucleus where it accumulates in nucleolus and stimulates ribosomal RNA (rRNA) transcription, thus facilitating cell growth and proliferation. Under stress conditions, ANG is accumulated in cytoplasmic compartments and modulates the production of tiRNA, a novel class of small RNA that is derived from tRNA and is induced by stress. tiRNA suppress global protein translation by inhibiting both cap-dependent and -independent translation including that mediated by weak IRESes. However, strong IRES-mediated translation, a mechanism often used by genes involved in pro-survival and anti-apoptosis, is not affected. Thus, ANG-mediated tiRNA reprogram protein translation, save anabolic energy, and promote cell survival. This recently uncovered function of ANG presents a novel mechanism of action in regulating cell growth and survival.
Shuping Li; Guo-Fu Hu
Related Documents :
21858038 - Tig3 tumor suppressor-dependent organelle redistribution and apoptosis in skin cancer c...
21741968 - Chromaffin cell transplant in spinal cord reduces secondary allodynia induced by formal...
502088 - Receptive-field properties of cells in the dorsal part of the albino rat's lateral geni...
22252828 - Sq109 targets mmpl3, a membrane transporter of trehalose monomycolate involved in mycol...
21646178 - A synchronous increase in hydraulic conductive capacity and mechanical support in conif...
10233308 - Expression of human hair keratin basic 1 in pilomatrixoma. a study of 128 cases.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  227     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-03-21     Completed Date:  2012-07-19     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2822-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Growth Processes / genetics
Cell Survival / genetics
Protein Biosynthesis / genetics
RNA, Transfer / genetics,  metabolism
Ribonuclease, Pancreatic / genetics*,  metabolism*
Stress, Physiological / genetics*
Grant Support
R01 CA105241/CA/NCI NIH HHS; R01 CA105241-07A1/CA/NCI NIH HHS; R01 NS065237/NS/NINDS NIH HHS; R01 NS065237-03/NS/NINDS NIH HHS; R01CA105241/CA/NCI NIH HHS; R01NS065237/NS/NINDS NIH HHS
Reg. No./Substance:
9014-25-9/RNA, Transfer; EC 3.1.27.-/angiogenin; EC, Pancreatic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cysteine-dependent ubiquitination of Pex18p is linked to cargo translocation across the peroxisomal ...
Next Document:  Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages.