| Emerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data. | |
MedLine Citation:
|
PMID: 23261354 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
INTRODUCTION: Myxomatous mitral valve is one of the most common heart valves diseases in human and has been well characterized at a functional and morphological level. Diseased valves are thickened as a result of extracellular matrix remodeling and proteoglycans accumulation accompanied by the disruption of the stratified structures of the leaflets. METHODS: Global transcriptomic analysis was used as a start-up to investigate potential pathogenic mechanisms involved in the development of the human idiopathic myxomatous mitral valve, which have been elusive for many years. RESULTS: These prospective analyses have highlighted the potential role of apparently unrelated molecules in myxomatous mitral valve such as members of the transforming growth factor-β superfamily, aggrecanases of the "a disintegrin and metalloprotease with thrombospondin repeats I" family, and a weakening of the protection against oxidative stress. We have integrated, in this review, recent transcriptomic data from our laboratory [A. Hulin, C.F. Deroanne, C.A. Lambert, B. Dumont, V. Castronovo, J.O. Defraigne, et al. Metallothionein-dependent up-regulation of TGF-beta2 participates in the remodelling of the myxomatous mitral valve. Cardiovasc Res 2012;93:480-489] and from the publication of Sainger et al. [R. Sainger, J.B. Grau, E. Branchetti, P. Poggio, W.F. Seefried, B.C. Field, et al. Human myxomatous mitral valve prolapse: role of bone morphogenetic protein 4 in valvular interstitial cell activation. J Cell Physiol 2012;227:2595-2604] with existing literature and information issued from the study of monogenic syndromes and animal models. CONCLUSION: Understanding cellular alterations and molecular mechanisms involved in myxomatous mitral valve should help at identifying relevant targets for future effective pharmacological therapy to prevent or reduce its progression. |
Authors:
|
Alexia Hulin; Christophe Deroanne; Charles Lambert; Jean-Olivier Defraigne; Betty Nusgens; Marc Radermecker; Alain Colige |
Related Documents
:
|
22846944 - Insertion of central venous catheters induces a hypercoagulable state. 23642024 - Wave intensity analysis in the human coronary circulation in health and disease. 23889354 - Vein of galen aneurysmal malformations: critical analysis of the literature with propos... 24003374 - Middle cerebral artery aneurysm in a premature neonate. 639534 - Long-term radial artery cannulation: effects on subsequent vessel function. 20619704 - Virtual angioscopy and 3d navigation: a new technique for analysis of the aortic arch a... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-20 |
Journal Detail:
|
Title: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology Volume: - ISSN: 1879-1336 ISO Abbreviation: Cardiovasc. Pathol. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9212060 Medline TA: Cardiovasc Pathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Laboratory of Connective Tissues Biology, GIGA, University of Liège, Liège, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Violence Exposure as a Predictor of Internalizing and Externalizing Problems Among Children of Subst...
Next Document: Risk of high-grade cervical intraepithelial neoplasia during follow-up in HPV-positive women accordi...