| Emerging nanotechnology-based strategies for the identification of microbial pathogenesis. | |
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MedLine Citation:
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PMID: 19914316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infectious diseases are still a major healthcare problem. From food intoxication and contaminated water, to hospital-acquired diseases and pandemics, infectious agents cause disease throughout the world. Despite advancements in pathogens' identification, some of the gold-standard diagnostic methods have limitations, including laborious sample preparation, bulky instrumentation and slow data readout. In addition, new field-deployable diagnostic modalities are urgently needed in first responder and point-of-care applications. Apart from compact, these sensors must be sensitive, specific, robust and fast, in order to facilitate detection of the pathogen even in remote rural areas. Considering these characteristics, researchers have utilized innovative approaches by employing the unique properties of nanomaterials in order to achieve detection of infectious agents, even in complex media like blood. From gold nanoparticles and their plasmonic shifts to iron oxide nanoparticles and changes in magnetic properties, detection of pathogens, toxins, antigens and nucleic acids has been achieved with impressive detection thresholds. Additionally, as bacteria become resistant to antibiotics, nanotechnology has achieved the rapid determination of bacterial drug susceptibility and resistance using novel methods, such as amperometry and magnetic relaxation. Overall, these promising results hint to the adoption of nanotechnology-based diagnostics for the diagnosis of infectious diseases in diverse settings throughout the globe, preventing epidemics and safeguarding human and economic wellness. |
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Authors:
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Charalambos Kaittanis; Santimukul Santra; J Manuel Perez |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-11-13 |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 62 ISSN: 1872-8294 ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-05-17 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 408-23 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Nanoscience Technology Center, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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analysis Antigens, Surface / analysis Bacterial Toxins / analysis Developing Countries Humans Infection / diagnosis*, microbiology* Microbial Sensitivity Tests Nanoparticles Nanotechnology / trends* Nucleic Acids / analysis |
| Grant Support | |
ID/Acronym/Agency:
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GM084331/GM/NIGMS NIH HHS; R01 GM084331-02/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens, Surface; 0/Bacterial Toxins; 0/Nucleic Acids |
| Comments/Corrections | |
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