Document Detail

Emerging model systems in evo-devo: cavefish and microevolution of development.
MedLine Citation:
PMID:  18460088     Owner:  NLM     Status:  MEDLINE    
Cavefish and their conspecific surface-dwelling ancestors (Astyanax mexicanus) are emerging as a model system to study the microevolution of development. Here we describe attributes that make this system highly promising for such studies. We review how the Astyanax system is being used to understand evolutionary forces underlying loss of eyes and pigmentation in cavefish. Pigment regression is probably explained by neutral mutations, whereas natural selection is a likely mechanism for loss of eyes. Finally, we discuss several research frontiers in which Astyanax is poised to make significant contributions in the future: evolution of constructive traits, the craniofacial skeleton, the central nervous system, and behavior.
William R Jeffery
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Evolution & development     Volume:  10     ISSN:  1525-142X     ISO Abbreviation:  Evol. Dev.     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-08-05     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  100883432     Medline TA:  Evol Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
Department of Biology, University of Maryland, College Park, MD 20742, USA.
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MeSH Terms
Biological Evolution*
Developmental Biology / methods*
Eye / anatomy & histology
Fishes / embryology*
Models, Animal*
Quantitative Trait Loci
Research Design
Grant Support
R01 EY014619/EY/NEI NIH HHS; R01-EY014619/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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