| Emerging insights in the management of hemoglobin E beta thalassemia. | |
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MedLine Citation:
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PMID: 20712787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Globally, hemoglobin (Hb) E beta thalassemia accounts for approximately half the severe forms of beta thalassemia. Because of its wide clinical diversity and the ability of patients with this condition to adapt unusually well to low hemoglobin levels, the management of Hb E beta thalassemia, particularly the decision to instigate regular blood transfusion, is particularly difficult. Here, we present a summary of our work in patients with this condition, which attempts to define clinical, adaptive, and genetic factors of possible value in determining the early management of this condition. |
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Authors:
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Nancy F Olivieri; Vivekanandan Thayalsuthan; Angela O'Donnell; Anuja Premawardhena; Christopher Rigobon; Giulia Muraca; Christopher Fisher; David J Weatherall |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1202 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 155-7 Citation Subset: IM |
Affiliation:
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Hemoglobinopathy Research Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. noliv@attglobal.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Transfusion Hemoglobin E* Humans beta-Thalassemia / physiopathology, therapy* |
| Chemical | |
Reg. No./Substance:
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9034-61-1/Hemoglobin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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