Document Detail

Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration.
MedLine Citation:
PMID:  21059749     Owner:  NLM     Status:  MEDLINE    
Adult mammalian central nervous system (CNS) axons have a limited regrowth capacity following injury. Myelin-associated inhibitors (MAIs) limit axonal outgrowth, and their blockage improves the regeneration of damaged fiber tracts. Three of these proteins, Nogo-A, MAG, and OMgp, share two common neuronal receptors: NgR1, together with its coreceptors [p75(NTR), TROY, and Lingo-1]; and the recently described paired immunoglobulin-like receptor B (PirB). These proteins impair neuronal regeneration by limiting axonal sprouting. Some of the elements involved in the myelin inhibitory pathways may still be unknown, but the discovery that blocking both PirB and NgR1 activities leads to near-complete release from myelin inhibition, sheds light on one of the most competitive and intense fields of neuroregeneration study in recent decades. In parallel with the identification and characterization of the roles and functions of these inhibitory molecules in axonal regeneration, data gathered in the field strongly suggest that most of these proteins have roles other than axonal growth inhibition. The discovery of a new group of interacting partners for myelin-associated receptors and ligands, as well as functional studies within or outside the CNS environment, highlights the potential new physiological roles for these proteins in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration.
Franc Llorens; Vanessa Gil; José Antonio del Río
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-11-08
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  25     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-01     Completed Date:  2011-04-04     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-75     Citation Subset:  IM    
Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia, and Department of Cell Biology, University of Barcelona, Barcelona, Spain.
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MeSH Terms
Gene Expression Regulation
Myelin Sheath / metabolism*
Nerve Tissue Proteins / genetics,  physiology*
Neurodegenerative Diseases / genetics,  metabolism*
Neuronal Plasticity / physiology*
Neurons / cytology*,  metabolism*
Reg. No./Substance:
0/Nerve Tissue Proteins

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