Document Detail


Emerging drugs for gastro-oesophageal reflux disease.
MedLine Citation:
PMID:  15934879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastro-oesophageal reflux disease is a common medical problem caused by the exposure of the distal oesophagus to gastric contents. Existing medical therapy is very effective, but symptomatic relief with acid suppressants is often delayed. Treatment focuses on the suppression of gastric acid rather than on the underlying pathophysiological abnormalities, such as transient non-swallow-related lower oesophageal sphincter relaxation. Current pharmacological developments concentrate on drugs with lasting acid suppression and a faster onset of action. Compounds interacting with the complex neuromuscular regulation of the gastro-oesophageal junction are also being developed and offer exciting prospects.
Authors:
Peter Wurm; John De Caestecker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on emerging drugs     Volume:  10     ISSN:  1744-7623     ISO Abbreviation:  Expert Opin Emerg Drugs     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2006-04-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101135662     Medline TA:  Expert Opin Emerg Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  457-71     Citation Subset:  IM    
Affiliation:
Digestive Diseases Centre, University Hospitals of Leicester, Leicester, UK. peter.wurm@uhl-tr.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Antacids / chemistry,  therapeutic use
Clinical Trials as Topic / statistics & numerical data
Drug Industry / trends*
Drugs, Investigational / chemistry,  therapeutic use*
Gastroesophageal Reflux / drug therapy*,  physiopathology
Gastrointestinal Agents / chemistry,  therapeutic use*
Humans
Chemical
Reg. No./Substance:
0/Antacids; 0/Drugs, Investigational; 0/Gastrointestinal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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