Document Detail


Emerging diuretics for the treatment of heart failure.
MedLine Citation:
PMID:  19196235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure continues to be a major global concern. Despite greater understanding of the 'maladaptive' mechanisms that contribute to its development and progression, morbidity and mortality from heart failure remain high. Existing treatment modalities have been hampered by the development of electrolyte abnormalities, diuretic resistance and the cardiorenal syndrome. This review focuses on the pharmacological properties and clinical data of therapeutic agents under investigation that target vasopressin and adenosine receptors for the treatment of patients with heart failure.
Authors:
Yabiz Sedghi; Krishna K Gaddam; Hector O Ventura
Related Documents :
10184925 - Clinical practice guidelines for heart failure.
8774385 - Heart failure--implications of the true size of the problem.
9761085 - Effects of prostacyclin on the pulmonary vascular tone and cardiac contractility of pat...
16227145 - A statin in the treatment of heart failure? controlled rosuvastatin multinational study...
9352455 - Mechanisms of infarction in the superficial posterior cerebral artery territory.
9286015 - Abnormal fetal cardiac axis in the detection of intrathoracic anomalies and congenital ...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on emerging drugs     Volume:  14     ISSN:  1744-7623     ISO Abbreviation:  Expert Opin Emerg Drugs     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-13     Completed Date:  2009-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135662     Medline TA:  Expert Opin Emerg Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  195-204     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Clinical Trials as Topic
Disease Progression
Diuretics / pharmacology,  therapeutic use*
Drug Delivery Systems*
Drug Resistance
Heart Failure / drug therapy*,  mortality,  physiopathology
Humans
Kidney Diseases / etiology,  physiopathology
Receptors, Purinergic P1 / antagonists & inhibitors
Receptors, Vasopressin / antagonists & inhibitors
Syndrome
Water-Electrolyte Imbalance / etiology
Chemical
Reg. No./Substance:
0/Diuretics; 0/Receptors, Purinergic P1; 0/Receptors, Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Generation of Correlated Spike Trains.
Next Document:  Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein recept...