Document Detail

Emerging diuretics for the treatment of heart failure.
MedLine Citation:
PMID:  19196235     Owner:  NLM     Status:  MEDLINE    
Heart failure continues to be a major global concern. Despite greater understanding of the 'maladaptive' mechanisms that contribute to its development and progression, morbidity and mortality from heart failure remain high. Existing treatment modalities have been hampered by the development of electrolyte abnormalities, diuretic resistance and the cardiorenal syndrome. This review focuses on the pharmacological properties and clinical data of therapeutic agents under investigation that target vasopressin and adenosine receptors for the treatment of patients with heart failure.
Yabiz Sedghi; Krishna K Gaddam; Hector O Ventura
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on emerging drugs     Volume:  14     ISSN:  1744-7623     ISO Abbreviation:  Expert Opin Emerg Drugs     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-13     Completed Date:  2009-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135662     Medline TA:  Expert Opin Emerg Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  195-204     Citation Subset:  IM    
Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA.
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MeSH Terms
Clinical Trials as Topic
Disease Progression
Diuretics / pharmacology,  therapeutic use*
Drug Delivery Systems*
Drug Resistance
Heart Failure / drug therapy*,  mortality,  physiopathology
Kidney Diseases / etiology,  physiopathology
Receptors, Purinergic P1 / antagonists & inhibitors
Receptors, Vasopressin / antagonists & inhibitors
Water-Electrolyte Imbalance / etiology
Reg. No./Substance:
0/Diuretics; 0/Receptors, Purinergic P1; 0/Receptors, Vasopressin

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