| Emerging diuretics for the treatment of heart failure. | |
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MedLine Citation:
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PMID: 19196235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart failure continues to be a major global concern. Despite greater understanding of the 'maladaptive' mechanisms that contribute to its development and progression, morbidity and mortality from heart failure remain high. Existing treatment modalities have been hampered by the development of electrolyte abnormalities, diuretic resistance and the cardiorenal syndrome. This review focuses on the pharmacological properties and clinical data of therapeutic agents under investigation that target vasopressin and adenosine receptors for the treatment of patients with heart failure. |
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Authors:
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Yabiz Sedghi; Krishna K Gaddam; Hector O Ventura |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on emerging drugs Volume: 14 ISSN: 1744-7623 ISO Abbreviation: Expert Opin Emerg Drugs Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-13 Completed Date: 2009-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135662 Medline TA: Expert Opin Emerg Drugs Country: England |
Other Details:
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Languages: eng Pagination: 195-204 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clinical Trials as Topic Disease Progression Diuretics / pharmacology, therapeutic use* Drug Delivery Systems* Drug Resistance Heart Failure / drug therapy*, mortality, physiopathology Humans Kidney Diseases / etiology, physiopathology Receptors, Purinergic P1 / antagonists & inhibitors Receptors, Vasopressin / antagonists & inhibitors Syndrome Water-Electrolyte Imbalance / etiology |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 0/Receptors, Purinergic P1; 0/Receptors, Vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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