| Emerging cardiometabolic complications of androgen deprivation therapy. | |
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MedLine Citation:
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PMID: 20148744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostate cancer (PCa) is the most common malignancy in men. Androgen deprivation therapy (ADT) is used in the treatment of locally advanced and metastatic PCa. Although its use has improved survival in a subset of patients, it also has negative consequences. Osteoporosis, sexual dysfunction, hot flashes and adverse changes in body composition are well-known and well-studied complications of ADT. Recent studies have also found metabolic complications in these men such as insulin resistance, diabetes and metabolic syndrome. In addition, these men might also experience higher cardiovascular mortality. Studies are needed to determine the mechanism behind these complications and to employ strategies to prevent them. |
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Authors:
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Karen Choong; Shehzad Basaria |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The aging male : the official journal of the International Society for the Study of the Aging Male Volume: 13 ISSN: 1473-0790 ISO Abbreviation: Aging Male Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-12 Completed Date: 2010-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808210 Medline TA: Aging Male Country: England |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androgen Antagonists
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adverse effects*,
therapeutic use Body Composition Cardiovascular Diseases / chemically induced, etiology* Gonadotropin-Releasing Hormone / agonists*, antagonists & inhibitors* Humans Male Osteoporosis / etiology Prostatic Neoplasms / drug therapy* Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 33515-09-2/Gonadotropin-Releasing Hormone; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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