| Emerging aspects of the adrenergic nervous systems. | |
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MedLine Citation:
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PMID: 6152887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present paper reviews some recent experiments with relevance to the functional significance of brain noradrenergic systems with bearing on three clinically relevant topics: 1. The withdrawal and abstinence reactions after the antihypertensive agent clonidine as well as after opiates. 2. The mental reactions associated with alterations in blood volume and acid-base balance. 3. The central actions and side-effects of beta-adrenoceptor blocking agents. The available evidence indicates that central NA neurons may serve a function within the CNS analogous to that of the peripheral sympathetic nerves, i.e. to alert and alarm the individual to significant events in the external and internal environment. Thus, the largest brain NA system, which emanates from locus coeruleus and innervates vast regions of the neuroaxis, is largely activated in the same situations and by the same mechanisms (e.g. blood-volume and chemoreceptors) as the sympathetic system, and may provide part of the central machinery for the anxiety reaction associated with hypercapnia as well as the withdrawal reactions after clonidine or morphine. Some, but not all centrally active beta-adrenoreceptor blocking agents were found to affect the activity of brain NA systems. This result suggests that there may be significant differences with respect to the clinical, central side effects of these drugs. |
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Authors:
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T Svensson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica. Supplementum Volume: 76 ISSN: 0515-2720 ISO Abbreviation: Acta Anaesthesiol Scand Suppl Publication Date: 1982 |
Date Detail:
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Created Date: 1989-04-06 Completed Date: 1989-04-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0370271 Medline TA: Acta Anaesthesiol Scand Suppl Country: DENMARK |
Other Details:
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Languages: eng Pagination: 8-11 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Animals Norepinephrine / physiology Rats Sympathetic Nervous System / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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