Document Detail

Emerging Roles for Lysophospholipid Mediators in Pregnancy.
MedLine Citation:
PMID:  24689547     Owner:  NLM     Status:  Publisher    
Recent progress in lipid research has unveiled new biologic roles for lysophospholipids as mediators of intercellular signaling. Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are representative lysophospholipids. Accumulating evidence suggests that, acting as intercellular mediators, these and other lysophospholipids may play important roles in physiological and pathological situations. This review discusses the possible involvement of LPA and S1P in reproductive processes, with a focus on the regulatory mechanisms of pregnancy maintenance. As LPA promotes prostaglandin synthesis, mediators in the LPA pathway may also play a significant role in implantation and parturition. S1P signaling is thought to be essential in vascular formation within the uteroplacental unit and in fetomaternal immunologic interactions. Derangements in either one of these lysophospholipid signaling pathways could result in pregnancy complications that may include implantation failure, preeclampsia, and preterm labor.
Takeshi Nagamatsu; Yuki Iwasawa-Kawai; Mayuko Ichikawa; Kei Kawana; Takahiro Yamashita; Yutaka Osuga; Tomoyuki Fujii; Danny J Schust
Related Documents :
12738107 - Short delay of delivery to allow corticosteroid administration in a case of preterm ant...
819897 - Methionine adenosyltransferase and transmethylation in fetal and neonatal lung of the h...
12796937 - Fetal laryngeal obstruction: sonographic detection.
11869947 - Hemoglobin f synthesis is not restricted to fetal erythropoietic organs during extramed...
22324917 - Prediction of selective fetal growth restriction and twin-to-twin transfusion syndrome ...
22505507 - Fetal magnetocardiography (fmcg): moving forward in the establishment of clinical refer...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-1
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  -     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Trust in physicians among rural medicaid-enrolled smokers.
Next Document:  Quanti?cation of Viral Proteins of the Avian H7 Subtype of In?uenza Virus-An Isotope Dilution Mass S...