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Emerging Role of the Ubiquitin Proteasome System in the Control of Shoot Apical Meristem Function.
MedLine Citation:
PMID:  23164365     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The shoot apical meristem (SAM) is a population of undifferentiated cells at the tip of the shoot axis that establishes early during plant embryogenesis and gives rise to all shoot organs throughout the plant's life. A plethora of different families of transcription factors (TFs) play a key role in establishing the equilibrium between cell differentiation and stem cell maintenance in the SAM. Fine tuning of these regulatory proteins is crucial for a proper and fast SAM response to environmental and hormonal cues, and for development progression. One effective way to rapidly inactivate TFs involves regulated proteolysis by the ubiquitin/26S proteasome system (UPS). However, a possible role of UPS-dependent protein degradation in the regulation of key shoot apical meristem transcription factors has not been thoroughly investigated. Here, we summarize recent evidence supporting a role for the UPS in SAM maintenance and function. We integrate this survey with an in silico analysis of publicly-available microarray databases which identified ubiquitin ligases that are expressed in specific areas within the SAM, suggesting that they might regulate or act downstream of meristem-specific factors.
Authors:
Elisabetta Di Giacomo; Giovanna Serino; Giovanna Frugis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-16
Journal Detail:
Title:  Journal of integrative plant biology     Volume:  -     ISSN:  1744-7909     ISO Abbreviation:  J Integr Plant Biol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101250502     Medline TA:  J Integr Plant Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Institute of Botany, Chinese Academy of Sciences.
Affiliation:
Istituto di Biologia e Biotecnologia Agraria, UOS Roma, Consiglio Nazionale delle Ricerche, Via Salaria Km. 29,300-00015, Monterotondo Scalo, Roma, Italy Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Piazzale Aldo Moro 5, 00185 Roma, Italy The New York Botanical Garden, Genomics Program NYBG, 2900 Southern Blvd. Bronx, NY 10458-5126, USA.
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