Document Detail


Emerging role of the bufadienolides in cardiovascular and kidney diseases.
MedLine Citation:
PMID:  20417001     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bufadienolides are a group of steroid hormones that circulate in blood and are excreted in urine. They have the ability to inhibit the adenosine triphosphatase sodium-potassium pump (Na(+)-K(+)-ATPase), with predilection for its alpha1 isoform. This capability enables them to share with other cardiac glycosides the facility to cause an increase in sodium excretion, produce vasoconstriction resulting in hypertension, and act as cardiac inotropes. Bufadienolides have been implicated in instances of volume expansion-mediated hypertension, syndromes in which they are considered capable of causing a vascular leak, interfering with cellular proliferation, and inhibiting cellular maturation. An antagonist to the most well-studied bufadienolide, marinobufagenin, is resibufogenin, a compound that provides promise for the treatment of disorders in which excessive levels of marinobufagenin are present and are etiopathogenetic.
Authors:
Jules B Puschett; Enoch Agunanne; Mohammad N Uddin
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-22
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  56     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-70     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Medicine, Division of Nephrology and Hypertension, Texas A&M College of Medicine/Scott & White, Temple, TX, USA. jpuschett@swmail.sw.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Volume / physiology
Bufanolides* / blood,  chemistry,  metabolism,  urine
Capillary Permeability / physiology
Cardiotonic Agents* / metabolism
Cytokines / physiology
Female
Heart Diseases / complications,  physiopathology*
Humans
Hypertension / physiopathology
Molecular Structure
Pre-Eclampsia / physiopathology*,  urine
Pregnancy
Renal Insufficiency, Chronic / complications,  physiopathology*
Vascular Resistance / physiology
Vasoconstrictor Agents / blood,  chemistry
Young Adult
Chemical
Reg. No./Substance:
0/Bufanolides; 0/Cardiotonic Agents; 0/Cytokines; 0/Vasoconstrictor Agents; 465-39-4/bufogenin; 470-42-8/marinobufagenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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