| Emerging role of the bufadienolides in cardiovascular and kidney diseases. | |
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MedLine Citation:
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PMID: 20417001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bufadienolides are a group of steroid hormones that circulate in blood and are excreted in urine. They have the ability to inhibit the adenosine triphosphatase sodium-potassium pump (Na(+)-K(+)-ATPase), with predilection for its alpha1 isoform. This capability enables them to share with other cardiac glycosides the facility to cause an increase in sodium excretion, produce vasoconstriction resulting in hypertension, and act as cardiac inotropes. Bufadienolides have been implicated in instances of volume expansion-mediated hypertension, syndromes in which they are considered capable of causing a vascular leak, interfering with cellular proliferation, and inhibiting cellular maturation. An antagonist to the most well-studied bufadienolide, marinobufagenin, is resibufogenin, a compound that provides promise for the treatment of disorders in which excessive levels of marinobufagenin are present and are etiopathogenetic. |
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Authors:
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Jules B Puschett; Enoch Agunanne; Mohammad N Uddin |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-22 |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 56 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 359-70 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Division of Nephrology and Hypertension, Texas A&M College of Medicine/Scott & White, Temple, TX, USA. jpuschett@swmail.sw.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Volume / physiology Bufanolides* / blood, chemistry, metabolism, urine Capillary Permeability / physiology Cardiotonic Agents* / metabolism Cytokines / physiology Female Heart Diseases / complications, physiopathology* Humans Hypertension / physiopathology Molecular Structure Pre-Eclampsia / physiopathology*, urine Pregnancy Renal Insufficiency, Chronic / complications, physiopathology* Vascular Resistance / physiology Vasoconstrictor Agents / blood, chemistry Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Bufanolides; 0/Cardiotonic Agents; 0/Cytokines; 0/Vasoconstrictor Agents; 465-39-4/bufogenin; 470-42-8/marinobufagenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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