| Emerging MRI methods in rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 21045791 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
New MRI techniques have been developed to assess not only the static anatomy of synovial hyperplasia, bone changes and cartilage degradation in patients with rheumatoid arthritis (RA), but also the activity of the physiological events that cause these changes. This enables an estimation of the rate of change in the synovium, bone and cartilage as a result of disease activity or in response to therapy. Typical MRI signs of RA in the pre-erosive phase include synovitis, bone marrow edema and subchondral cyst formation. Synovitis can be assessed by T2-weighted imaging, dynamic contrast-enhanced MRI or diffusion tensor imaging. Bone marrow edema can be detected on fluid-sensitive sequences such as short-tau inversion recovery or T2-weighted fast-spin echo sequences. Detection of small bone erosions in the early erosive phase using T1-weighted MRI has sensitivity comparable to CT. Numerous MRI techniques have been developed for quantitative assessment of potentially pathologic changes in cartilage composition that occur before frank morphologic changes. In this Review, we summarize the advances and new directions in the field of MRI, with an emphasis on their current state of development and application in RA. |
| | |
Authors:
|
Camilo G Borrero; James M Mountz; John D Mountz |
Publication Detail:
|
Type: Journal Article Date: 2010-11-02 |
Journal Detail:
|
Title: Nature reviews. Rheumatology Volume: 7 ISSN: 1759-4804 ISO Abbreviation: Nat Rev Rheumatol Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101500080 Medline TA: Nat Rev Rheumatol Country: United States |
Other Details:
|
Languages: eng Pagination: 85-95 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endothelial dysfunction as a potential contributor in diabetic nephropathy.
Next Document: Genome-wide association studies and genetic risk assessment of liver diseases.