Document Detail


Emerging Corynebacterium glutamicum systems biology.
MedLine Citation:
PMID:  16406159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corynebacterium glutamicum is widely used for the biotechnological production of amino acids. Amino acid producing strains have been improved classically by mutagenesis and screening as well as in a rational manner using recombinant DNA technology. Metabolic flux analysis may be viewed as the first systems approach to C. glutamicum physiology since it combines isotope labeling data with metabolic network models of the biosynthetic and central metabolic pathways. However, only the complete genome sequence of C. glutamicum and post-genomics methods such as transcriptomics and proteomics have allowed characterizing metabolic and regulatory properties of this bacterium on a truly global level. Besides transcriptomics and proteomics, metabolomics and modeling approaches have now been established. Systems biology, which uses systematic genomic, proteomic and metabolomic technologies with the final aim of constructing comprehensive and predictive models of complex biological systems, is emerging for C. glutamicum. We will present current developments that advanced our insight into fundamental biology of C. glutamicum and that in the future will enable novel biotechnological applications for the improvement of amino acid production.
Authors:
Volker F Wendisch; Michael Bott; Jörn Kalinowski; Marco Oldiges; Wolfgang Wiechert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-01-10
Journal Detail:
Title:  Journal of biotechnology     Volume:  124     ISSN:  0168-1656     ISO Abbreviation:  J. Biotechnol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-07     Completed Date:  2006-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411927     Medline TA:  J Biotechnol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  74-92     Citation Subset:  IM    
Affiliation:
Institute of Biotechnology 1, Research Center Juelich, Germany. v.wendisch@fz-juelich.de
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / biosynthesis
Biotechnology
Corynebacterium glutamicum / chemistry,  genetics*,  metabolism*
Gene Expression Regulation, Bacterial
Genome, Bacterial*
Genomics*
Proteomics
Systems Biology / trends*
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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