| The Emerging Application of Remote Ischemic Conditioning in the Clinical Arena. | |
| | |
MedLine Citation:
|
PMID: 22858831 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Remote ischemic conditioning (RIC) is an intervention in which intermittent episodes of ischemia and reperfusion in an organ or tissue distant from the target organ requiring protection, provide armour against lethal ischemia-reperfusion injury. Although the exact mechanisms underlying the protection mediated through RIC have not been clearly established, the release of humoral factors and the activation of neural pathways have been implicated. There is now clinical evidence suggesting that this form of protection can be induced by a simple, non-invasive and cost-effective procedure such as inflation and deflation of a blood pressure cuff and that this intervention provides increased organ protection in a variety of clinical scenarios, e.g. in myocardial infarction. Here we provide an overview of the history and evolution of RIC, the potential mechanisms underlying its protective effects, and published randomized clinical trials in cardiovascular procedures. |
| | |
Authors:
|
Tuncay Yetgin; Olivier C Manintveld; Fahriye Groen; Buket Tas; Arie P Kappetein; Robert-Jan van Geuns; Felix Zijlstra; Dirk J Duncker; Wim J van der Giessen |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-1 |
Journal Detail:
|
Title: Cardiology in review Volume: - ISSN: 1538-4683 ISO Abbreviation: Cardiol Rev Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9304686 Medline TA: Cardiol Rev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands. 2Interuniversity Cardiology Institute of the Netherlands, ICIN-KNAW, Utrecht, the Netherlands. 3Department of Cardio-Thoracic Surgery, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Single neuron capture and axonal development in three-dimensional microscale hydrogels.
Next Document: Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment.