Document Detail

The Emerging Application of Remote Ischemic Conditioning in the Clinical Arena.
MedLine Citation:
PMID:  22858831     Owner:  NLM     Status:  Publisher    
Remote ischemic conditioning (RIC) is an intervention in which intermittent episodes of ischemia and reperfusion in an organ or tissue distant from the target organ requiring protection, provide armour against lethal ischemia-reperfusion injury. Although the exact mechanisms underlying the protection mediated through RIC have not been clearly established, the release of humoral factors and the activation of neural pathways have been implicated. There is now clinical evidence suggesting that this form of protection can be induced by a simple, non-invasive and cost-effective procedure such as inflation and deflation of a blood pressure cuff and that this intervention provides increased organ protection in a variety of clinical scenarios, e.g. in myocardial infarction. Here we provide an overview of the history and evolution of RIC, the potential mechanisms underlying its protective effects, and published randomized clinical trials in cardiovascular procedures.
Tuncay Yetgin; Olivier C Manintveld; Fahriye Groen; Buket Tas; Arie P Kappetein; Robert-Jan van Geuns; Felix Zijlstra; Dirk J Duncker; Wim J van der Giessen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-1
Journal Detail:
Title:  Cardiology in review     Volume:  -     ISSN:  1538-4683     ISO Abbreviation:  Cardiol Rev     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands. 2Interuniversity Cardiology Institute of the Netherlands, ICIN-KNAW, Utrecht, the Netherlands. 3Department of Cardio-Thoracic Surgery, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands.
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