Document Detail

Emergent equivalence relations between interoceptive (drug) and exteroceptive (visual) stimuli.
MedLine Citation:
PMID:  1645104     Owner:  NLM     Status:  MEDLINE    
Conditional "if-then" relations between drug (interoceptive) stimuli and visual (exteroceptive) stimuli were taught to 4 normal humans. Interoceptive stimuli were the effects produced by 0.32 mg/70 kg triazolam (a prototypical benzodiazepine) and placebo (lactose-filled capsules); exteroceptive stimuli were black symbols on white flash cards. Following the training of the prerequisite conditional relations, tests of emergent relations were conducted between exteroceptive stimuli and between interoceptive and exteroceptive stimuli. Equivalence relations emerged immediately without explicit training for all 4 subjects. Accuracy of responding during the interoceptive-exteroceptive equivalence tests and subjects' self-reports showed consistent discrimination between the drug effects of triazolam and placebo. Finally, a generalization test assessed whether a novel visual stimulus presented in the context of the placebo (i.e., no drug) would generalize to visual stimuli belonging to the placebo stimulus class. All 3 subjects who completed this test reliably chose the visual stimuli belonging to the placebo class and not the visual stimuli belonging to the triazolam stimulus class. The development of equivalence relations between interoceptive and exteroceptive stimuli demonstrates that private and public stimulus events can emerge as members of the same equivalence class. Theoretical and clinical implications are discussed.
R J DeGrandpre; W K Bickel; S T Higgins
Related Documents :
22782244 - Nitric oxide is involved in light-specific responses of tomato during germination under...
22418674 - Photon management with core-shell nanowire structures.
2922454 - Stimulus novelty and significance as determinants of electrodermal responsivity: the se...
1082014 - Effects of luminance and stimulus distance on accommodation and visual resolution.
7153914 - Is action potential duration of the intact dog heart related to contractility or stimul...
15233924 - Posterior parietal cortex neurons encode target motion in world-centered coordinates.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the experimental analysis of behavior     Volume:  58     ISSN:  0022-5002     ISO Abbreviation:  J Exp Anal Behav     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-10     Completed Date:  1992-09-10     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  0203727     Medline TA:  J Exp Anal Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-18     Citation Subset:  IM    
University of Vermont, Burlington 05401-1419.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arousal / drug effects*
Association Learning / drug effects*
Conditioning, Classical / drug effects
Discrimination Learning / drug effects*
Internal-External Control*
Pattern Recognition, Visual / drug effects*
Triazolam / pharmacology*
Grant Support
DA-04545/DA/NIDA NIH HHS; R01 06205//PHS HHS; T32 DA-07242/DA/NIDA NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of cocaine and alcohol, alone and in combination, on human learning and performance.
Next Document:  Experiences and attitudes about faith healing among family physicians.