Document Detail

Emergency department use of flumazenil prior to poison center consultation.
MedLine Citation:
PMID:  9251178     Owner:  NLM     Status:  MEDLINE    
We studied the frequency of use of flumazenil by emergency departments in our region and compared it to recommendations made by specialists in poison information at our poison control center. For a 5-mo period, we prospectively collected cases involving benzodiazepines or zolpidem. Data was documented only from calls from emergency departments. Emergency department personnel were asked the following: If given, the dose and frequency, contraindications, and adverse reactions. Each case was followed to completion. Flumazenil was not given in 55 cases. Of the remaining 14 cases in which it was given, 10 of the cases received flumazenil prior to poison control center consultation. We noted 1 case of dizziness. Ten cases given flumazenil had contraindications (eg ethanol abuse or possible seizurogenic coingestants). Despite possible contraindications, flumazenil was given 10/14 times (71%) prior to calling the poison control center. These results point to potential overuse of this antidote where contraindications or cautions are suspected in the overdosed patients. Our study suggests that when flumazenil use is contemplated by an emergency department physician, a poison control center consult may have a contrary recommendation.
T Burda; J B Leikin; C Fischbein; K Woods; S Aks
Related Documents :
1119768 - Methyl iodide intoxication. a case report.
1621358 - Case reports of lead poisoning in dogs from the national animal poison control center a...
20825388 - Acute 1,2,3-trichloropane poisoning: a case report and literature review.
23464838 - Complications after polymethylmethacrylate (pmma) injections in the face: a literature ...
2184498 - Acute appendicitis complicating infectious mononucleosis: case report and review.
18795848 - Rabies surveillance in the united states during 2007.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  39     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-04     Completed Date:  1997-09-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Rush Poison Control Center, Chicago, IL, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antidotes / contraindications,  therapeutic use*
Benzodiazepines / poisoning*
Flumazenil / contraindications,  therapeutic use*
Hypnotics and Sedatives / poisoning*
Overdose / drug therapy*
Poison Control Centers
Pyridines / poisoning*
Treatment Outcome
Reg. No./Substance:
0/Antidotes; 0/Hypnotics and Sedatives; 0/Pyridines; 12794-10-4/Benzodiazepines; 78755-81-4/Flumazenil; 82626-48-0/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MDEA related death in Crete: a case report and literature review.
Next Document:  Plant exposures ... a national profile of the most common plant genera.