| Emergency department use of flumazenil prior to poison center consultation. | |
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MedLine Citation:
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PMID: 9251178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the frequency of use of flumazenil by emergency departments in our region and compared it to recommendations made by specialists in poison information at our poison control center. For a 5-mo period, we prospectively collected cases involving benzodiazepines or zolpidem. Data was documented only from calls from emergency departments. Emergency department personnel were asked the following: If given, the dose and frequency, contraindications, and adverse reactions. Each case was followed to completion. Flumazenil was not given in 55 cases. Of the remaining 14 cases in which it was given, 10 of the cases received flumazenil prior to poison control center consultation. We noted 1 case of dizziness. Ten cases given flumazenil had contraindications (eg ethanol abuse or possible seizurogenic coingestants). Despite possible contraindications, flumazenil was given 10/14 times (71%) prior to calling the poison control center. These results point to potential overuse of this antidote where contraindications or cautions are suspected in the overdosed patients. Our study suggests that when flumazenil use is contemplated by an emergency department physician, a poison control center consult may have a contrary recommendation. |
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Authors:
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T Burda; J B Leikin; C Fischbein; K Woods; S Aks |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Veterinary and human toxicology Volume: 39 ISSN: 0145-6296 ISO Abbreviation: Vet Hum Toxicol Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-04 Completed Date: 1997-09-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7704194 Medline TA: Vet Hum Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 245-7 Citation Subset: IM |
Affiliation:
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Rush Poison Control Center, Chicago, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antidotes
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contraindications,
therapeutic use* Benzodiazepines / poisoning* Flumazenil / contraindications, therapeutic use* Humans Hypnotics and Sedatives / poisoning* Overdose / drug therapy* Poison Control Centers Pyridines / poisoning* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antidotes; 0/Hypnotics and Sedatives; 0/Pyridines; 12794-10-4/Benzodiazepines; 78755-81-4/Flumazenil; 82626-48-0/zolpidem |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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