Document Detail


Emergency department use of flumazenil prior to poison center consultation.
MedLine Citation:
PMID:  9251178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the frequency of use of flumazenil by emergency departments in our region and compared it to recommendations made by specialists in poison information at our poison control center. For a 5-mo period, we prospectively collected cases involving benzodiazepines or zolpidem. Data was documented only from calls from emergency departments. Emergency department personnel were asked the following: If given, the dose and frequency, contraindications, and adverse reactions. Each case was followed to completion. Flumazenil was not given in 55 cases. Of the remaining 14 cases in which it was given, 10 of the cases received flumazenil prior to poison control center consultation. We noted 1 case of dizziness. Ten cases given flumazenil had contraindications (eg ethanol abuse or possible seizurogenic coingestants). Despite possible contraindications, flumazenil was given 10/14 times (71%) prior to calling the poison control center. These results point to potential overuse of this antidote where contraindications or cautions are suspected in the overdosed patients. Our study suggests that when flumazenil use is contemplated by an emergency department physician, a poison control center consult may have a contrary recommendation.
Authors:
T Burda; J B Leikin; C Fischbein; K Woods; S Aks
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  39     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-04     Completed Date:  1997-09-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Affiliation:
Rush Poison Control Center, Chicago, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Antidotes / contraindications,  therapeutic use*
Benzodiazepines / poisoning*
Flumazenil / contraindications,  therapeutic use*
Humans
Hypnotics and Sedatives / poisoning*
Overdose / drug therapy*
Poison Control Centers
Pyridines / poisoning*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antidotes; 0/Hypnotics and Sedatives; 0/Pyridines; 12794-10-4/Benzodiazepines; 78755-81-4/Flumazenil; 82626-48-0/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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