| Emergency management of acute ischemic stroke. | |
MedLine Citation:
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PMID: 20454874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the advent of new therapeutic options for acute ischemic stroke, expeditious evaluation of patients with suspected stroke has become imperative. Goals of the initial evaluation are to determine the time of symptom onset, severity of the neurologic deficit, and to exclude intracranial hemorrhage and other mimics of acute ischemic stroke. CT and MRI perfusion studies may demonstrate the presence of an ischemic penumbra and aid in identification of patients who may benefit from thrombolysis. Intravenous recombinant tissue plasminogen activator (IV rtPA) remains the gold standard for acute ischemic stroke treatment, and the therapeutic time window recently has been extended to 4.5 h in certain patients. Catheter-based intra-arterial thrombolysis is being used increasingly as "rescue therapy" after IV rtPA and as primary therapy in select patients who are ineligible for intravenous therapy. Trials investigating the efficacy and safety of intra-arterial therapy are ongoing. |
Authors:
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Neelofer Shafi; Joshua M Levine |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 12 ISSN: 1534-6242 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 230-5 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Ischemia
/
diagnosis,
therapy* Cardiovascular Agents / therapeutic use Emergencies Fibrinolytic Agents / administration & dosage* Humans Stroke / diagnosis, therapy* Telemedicine Tissue Plasminogen Activator / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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