Document Detail

Emergency management of acute ischemic stroke.
MedLine Citation:
PMID:  20454874     Owner:  NLM     Status:  MEDLINE    
With the advent of new therapeutic options for acute ischemic stroke, expeditious evaluation of patients with suspected stroke has become imperative. Goals of the initial evaluation are to determine the time of symptom onset, severity of the neurologic deficit, and to exclude intracranial hemorrhage and other mimics of acute ischemic stroke. CT and MRI perfusion studies may demonstrate the presence of an ischemic penumbra and aid in identification of patients who may benefit from thrombolysis. Intravenous recombinant tissue plasminogen activator (IV rtPA) remains the gold standard for acute ischemic stroke treatment, and the therapeutic time window recently has been extended to 4.5 h in certain patients. Catheter-based intra-arterial thrombolysis is being used increasingly as "rescue therapy" after IV rtPA and as primary therapy in select patients who are ineligible for intravenous therapy. Trials investigating the efficacy and safety of intra-arterial therapy are ongoing.
Neelofer Shafi; Joshua M Levine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  12     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-5     Citation Subset:  IM    
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA.
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MeSH Terms
Brain Ischemia / diagnosis,  therapy*
Cardiovascular Agents / therapeutic use
Fibrinolytic Agents / administration & dosage*
Stroke / diagnosis,  therapy*
Tissue Plasminogen Activator / administration & dosage*
Reg. No./Substance:
0/Cardiovascular Agents; 0/Fibrinolytic Agents; EC Plasminogen Activator

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