| Emergency department care for patients with hemophilia and von Willebrand disease. | |
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MedLine Citation:
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PMID: 18757163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with bleeding disorders such as hemophilia A, hemophilia B, and von Willebrand disease (VWD) are routinely treated at home, with their care managed in specialized centers. In emergency situations, these patients often present to their local emergency department (ED), where their management can represent a challenge to the emergency physicians and staff who rarely encounter them. Delays in diagnosis and administration of replacement therapy are the factors most commonly identified as predictive of death. Patients and family members are often very well educated in the disease and its management, which can significantly reduce morbidity and mortality. Children with bleeding disorders confer different challenges to the emergency physician and staff: they may present with no obvious signs of trauma or they may present with bruises consistent with non-accidental injury. All possible causes of bruising/bleeding should be investigated, although treatment should be administered promptly. The initial presentation of a bleeding disorder in the pediatric population is often made in the ED. Treatment of hemophilia A and B requires rapid replacement of the deficient clotting factor, with the desired factor level and dosage dependent on the product used and the hemorrhagic situation encountered. In patients with VWD, the main treatments are desmopressin or intravenous infusion of plasma-derived concentrates containing factor VIII and von Willebrand factor. The aim of this review is to outline some of the issues facing emergency physicians and the options available for the treatment of patients with hemophilia A, hemophilia B, and VWD. |
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Authors:
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Tammuella Singleton; Rebecca Kruse-Jarres; Cindy Leissinger |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-08-30 |
Journal Detail:
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Title: The Journal of emergency medicine Volume: 39 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 158-65 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Inc. |
Affiliation:
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Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Coagulants / therapeutic use* Emergency Service, Hospital Hemophilia A / diagnosis, drug therapy*, physiopathology Hemophilia B / diagnosis, drug therapy*, physiopathology Hemostatics / therapeutic use Humans Recombinant Proteins / therapeutic use von Willebrand Diseases / diagnosis, drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Coagulants; 0/Hemostatics; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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