| Emergence and widespread dissemination of OXA-23, -24/40 and -58 carbapenemases among Acinetobacter spp. in Asia-Pacific nations: report from the SENTRY Surveillance Program. | |
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MedLine Citation:
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PMID: 18957398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to evaluate the occurrence and dissemination of acquired carbapenem-hydrolysing class D beta-lactamase (class D carbapenemase)- and metallo-beta-lactamase (MBL)-encoding genes among Acinetobacter spp. isolates recovered from medical centres in the Asia-Pacific (APAC) region. METHODS: During 2006-07, 41 medical centres located in 10 countries in the APAC region forwarded to a central monitoring site 544 Acinetobacter spp. isolates, which were tested for susceptibility by the reference broth microdilution method. Isolates non-susceptible to imipenem or meropenem (MIC>or=8 mg/L) were screened for OXA-23-, OXA-24/40-, OXA-58- and MBL-encoding genes and confirmed by sequencing. Clonality was assessed by ribotyping and PFGE. RESULTS: Polymyxins (99.1% susceptible) and tigecycline (98.9% susceptible) were the most active antimicrobial agents tested. Among the isolates, 230 (42.3%) were non-susceptible to imipenem or meropenem, and class D carbapenemase- or MBL-encoding genes were detected in 162 (70.4%). blaOXA-23 was found in isolates recovered from six countries, while blaOXA-24/40 and blaOXA-58 were less common. Several isolates harboured more than one class D carbapenemase, and MBL-encoding genes were detected in one Acinetobacter johnsonii from the Philippines (blaIMP-4) and one Acinetobacter baumannii from Korea (blaVIM-2)). Overall, clonal dissemination was noted within medical centres; however, genetic relatedness was also noted among class D carbapenemase-producing A. baumannii isolates recovered from different countries. CONCLUSIONS: This study shows a high distribution of class D carbapenemase-encoding genes, mainly blaOXA-23, in Acinetobacter spp. isolates. In addition, clonal dissemination among medical centres located in different countries in the APAC region, previously documented in many regions of Europe, emphasizes the epidemic potential of these bacteria. |
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Authors:
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Rodrigo E Mendes; Jan M Bell; John D Turnidge; Mariana Castanheira; Ronald N Jones |
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Publication Detail:
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Type: Journal Article Date: 2008-10-27 |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 63 ISSN: 1460-2091 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-01-23 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: England |
Other Details:
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Languages: eng Pagination: 55-9 Citation Subset: IM |
Affiliation:
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JMI Laboratories, North Liberty, IA 52317, USA. rodrigo-mendes@jmilabs.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acinetobacter
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classification,
drug effects*,
enzymology*,
isolation & purification Acinetobacter Infections / epidemiology*, microbiology* Anti-Bacterial Agents / pharmacology* Asia / epidemiology Australasia Bacterial Typing Techniques Cluster Analysis DNA Fingerprinting DNA, Bacterial / genetics Electrophoresis, Gel, Pulsed-Field Genotype Humans Microbial Sensitivity Tests Molecular Epidemiology Ribotyping beta-Lactam Resistance* beta-Lactamases / biosynthesis*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/DNA, Bacterial; EC 3.5.2.6/beta-Lactamases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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