Document Detail


Emergence of therapy-unrelated CML on a background of BCR-ABL-negative JAK2V617F-positive chronic idiopathic myelofibrosis.
MedLine Citation:
PMID:  18448166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the emergence of a chronic myeloid leukaemia (CML) during the course of a JAK2V617F-positive chronic idiopathic myelofibrosis (CIMF) in the absence of any myelosuppressive treatment. Although a response to imatinib was observed, the underlying myelofibrosis persisted after treatment and hydroxyurea was finally added to control the persistent thrombocytosis. Such rare patients with co-existing BCR-ABL translocation and JAK2V617F mutation must be identified in view of the possibility of targeted therapies. Moreover, the detection of BCR-ABL translocation appears to be crucial especially in the case of treated CIMF with an atypical course to identify CML before acute transformation.
Authors:
Laurent Jallades; Sandrine Hayette; Isabelle Tigaud; Anna Johnston; Bertrand Coiffier; Jean-Pierre Magaud; Martine Ffrench
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-04-29
Journal Detail:
Title:  Leukemia research     Volume:  32     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-08-28     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1608-10     Citation Subset:  IM    
Affiliation:
Laboratoire d'Hématologie, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Substitution
Chronic Disease
Fusion Proteins, bcr-abl / genetics
Humans
Janus Kinase 2 / genetics*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications,  diagnosis*
Male
Middle Aged
Point Mutation
Primary Myelofibrosis / complications*,  diagnosis,  drug therapy
RNA, Messenger / analysis
Chemical
Reg. No./Substance:
0/Fusion Proteins, bcr-abl; 0/RNA, Messenger; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human
Comments/Corrections
Comment In:
Leuk Res. 2008 Oct;32(10):1489-90   [PMID:  18439674 ]

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