Document Detail


Emergence of resting state networks in the preterm human brain.
MedLine Citation:
PMID:  21041625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The functions of the resting state networks (RSNs) revealed by functional MRI remain unclear, but it has seemed possible that networks emerge in parallel with the development of related cognitive functions. We tested the alternative hypothesis: that the full repertoire of resting state dynamics emerges during the period of rapid neural growth before the normal time of birth at term (around 40 wk of gestation). We used a series of independent analytical techniques to map in detail the development of different networks in 70 infants born between 29 and 43 wk of postmenstrual age (PMA). We characterized and charted the development of RSNs from recognizable but often fragmentary elements at 30 wk of PMA to full facsimiles of adult patterns at term. Visual, auditory, somatosensory, motor, default mode, frontoparietal, and executive control networks developed at different rates; however, by term, complete networks were present, several of which were integrated with thalamic activity. These results place the emergence of RSNs largely during the period of rapid neural growth in the third trimester of gestation, suggesting that they are formed before the acquisition of cognitive competencies in later childhood.
Authors:
Valentina Doria; Christian F Beckmann; Tomoki Arichi; Nazakat Merchant; Michela Groppo; Federico E Turkheimer; Serena J Counsell; Maria Murgasova; Paul Aljabar; Rita G Nunes; David J Larkman; Geraint Rees; A David Edwards
Related Documents :
3102125 - Percentile estimates of reference values for total protein and albumin in sera of prema...
6577775 - Transepidermal water loss in full-term and pre-term infants.
8399795 - Erythrocyte li+i-na+o countertransport in the newborn.
633025 - Olfactory reflexes in the newborn infant.
22240885 - Ecthyma gangrenosum in a premature low-birth-weight newborn.
6775525 - Elevated meconium lactase activity. its use as a screening test for cystic fibrosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-01
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  107     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2010-12-21     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20015-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bias (Epidemiology)
Brain / physiopathology*
Female
Gestational Age
Humans
Infant
Nerve Net / physiopathology*
Pregnancy
Pregnancy Trimester, Third / physiology
Premature Birth / physiopathology*
Regression Analysis
Rest / physiology*
Grant Support
ID/Acronym/Agency:
082334//Wellcome Trust; G1100809//Medical Research Council; MC_U120081323//Medical Research Council; MC_U120085814//Medical Research Council; MC_U120097117//Medical Research Council; //Medical Research Council; //Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model o...
Next Document:  Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation.