Document Detail


Emergence of resistance of vancomycin-resistant Enterococcus faecium in a thermal injury patient treated with quinupristin-dalfopristin and cultured epithelial autografts for wound closure.
MedLine Citation:
PMID:  12417169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vancomycin-resistant Enterococcus faecium and faecalis (VRE) remains a major complication among critically ill patients. A 26-year-old patient with 65% total body surface area burns (TBSA) was infected with several E. faecium strains during his admission that were resistant to vancomycin. Because chloramphenicol was the standard treatment at this time, this drug was initiated until, the organism was identified as E. faecium and reported as susceptible to quinupristin-dalfopristin. Given these data, it was then decided to discontinue the chloramphenicol therapy. Quinupristin-dalfopristin therapy resulted in initial reduction of fever and white blood cell counts that continued over the next 5 days. However, on day 7 of quinupristin-dalfopristin therapy, a return of fever and elevation of the white blood cell count was noted and a repeated E. faecium blood culture demonstrated sudden resistance to quinupristin-dalfopristin (Bauer-Kirby zone size <14 mm). Chloramphenicol was restarted and the patient improved slowly over a period of 16 days. Our indigenous VRE had limited exposure to quinupristin-dalfopristin in the recent past; however, resistance emerged with the first commercial use of this agent in our burn treatment center. High-dose chloramphenicol treatment did not appear to impair engraftment of cultured epithelial autografts (CEA) in this patient.
Authors:
Christina M Rose; Kathleen J Reilly; Linwood R Haith; Mary L Patton; Robert J Guilday; Michael J Cawley; Bruce H Ackerman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  28     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-05     Completed Date:  2003-03-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-8     Citation Subset:  IM    
Affiliation:
Health System/Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond, VA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Burns / therapy*
Chloramphenicol / therapeutic use
Cross Infection / drug therapy*
Drug Resistance, Multiple, Bacterial
Enterococcus faecium / drug effects*
Graft Survival
Gram-Positive Bacterial Infections / drug therapy*
Humans
Male
Skin Transplantation
Vancomycin Resistance*
Virginiamycin / pharmacology*
Chemical
Reg. No./Substance:
11006-76-1/Virginiamycin; 126602-89-9/quinupristin-dalfopristin; 56-75-7/Chloramphenicol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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