Document Detail


Emergence of resistance in staphylococci after long-term mupirocin application in patients on continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  15384798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we evaluated the effects of once-weekly mupirocin application to catheter exit sites on Staphylococcus aureus and coagulase-negative staphylococcus (CNS) colonization and investigated the resistance of those bacteria to methicillin (MeR) and mupirocin (MuR). We enrolled 36 continuous ambulatory peritoneal dialysis (CAPD) patients (mean age: 55.1 +/- 1.4 years) into the study. The patients (men/women: 21/15) had been applying mupirocin to the catheter exit site once weekly before the start of the study (mupirocin treatment duration: 3.1 +/- 2.0 years). During the study period, swabs were taken monthly from the nares, axillae, inguinal area, and catheter exit site. The swabs were inoculated on blood plates. Methicillin and mupirocin susceptibility were tested by disc diffusion according to the interpretative criteria of the National Committee for Clinical Laboratory Standards. We evaluated a total of 144 cultures. Among CNS isolates, the MuR was 66%, and the MeR was 38.8%. At the start of the study period, 3 patients were S. aureus nasal carriers. In nasal swabs, no MeR S. aureus was identified, and only 1 MuR S. aureus was found. Once-weekly application of mupirocin at the exit site in CAPD patients led to comparable rates of colonization by MuR S. aureus as did thrice-weekly or more frequent application. Clinical results showing high mupirocin and methicillin resistance in CNS are controversial.
Authors:
Caner Cavdar; Tuba Atay; Mujdat Zeybel; Ali Celik; Ayse Ozder; Serkan Yildiz; Zeynep Gulay; Taner Camsari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  20     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-23     Completed Date:  2004-11-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Dokuz Eylul University, School of Medicine, Izmir, Turkey. caner.cavdar@deu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage*
Antibiotic Prophylaxis*
Carrier State / microbiology
Catheters, Indwelling / adverse effects
Coagulase / metabolism
Drug Resistance
Female
Humans
Male
Methicillin Resistance
Middle Aged
Mupirocin / administration & dosage*
Peritoneal Dialysis, Continuous Ambulatory*
Staphylococcus / drug effects*,  enzymology,  isolation & purification
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Coagulase; 12650-69-0/Mupirocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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