| Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock. | |
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MedLine Citation:
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PMID: 21359606 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To assess the prevalence and predictive value of natural autoantibodies to high-mobility group box 1 (HMGB1) during sepsis. METHODS: Anti-HMGB1 and anti-human serum albumin (HSA) autoantibodies were detected by ELISA in 178 plasma samples longitudinally collected from 40 critically ill patients with septic shock. One hundred thirty-two plasma samples from healthy donors were used as control. RESULTS: IgGs to HMGB1 were detected in 15/40 patients (37.5%). The prevalence of anti-HMGB1 antibodies was significantly higher in the patients who survived (55%) compared to the patients who did not (20%) (p < 0.0001). The detection of anti-HMGB1 antibodies during the course of the disease was significantly associated with patient survival (p = 0.038). Moreover, there is a progressive and significant emergence of anti-HMGB1 antibodies during the course of the disease, mostly in patients who survived. CONCLUSIONS: This study shows that autoantibodies to HMGB1 are produced during sepsis and are associated with a favorable outcome in patients undergoing septic shock. |
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Authors:
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Stéphanie Barnay-Verdier; Lakhdar Fattoum; Chloé Borde; Srini Kaveri; Sébastien Gibot; Vincent Maréchal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-26 |
Journal Detail:
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Title: Intensive care medicine Volume: - ISSN: 1432-1238 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMRS 872, escalier F 2ème étage, 15 rue de l'école de médecine, Paris, 75006, France, stephanie.barnay-verdier@upmc.fr. |
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