Document Detail

Emergence of antimicrobial-resistant serotype 19A Streptococcus pneumoniae--Massachusetts, 2001-2006.
MedLine Citation:
PMID:  17947966     Owner:  NLM     Status:  MEDLINE    
Streptococcus pneumoniae (pneumococcus) is a leading cause of otitis, sinusitis, pneumonia, and meningitis worldwide. Treatment of the most serious type of pneumococcal infection, invasive pneumococcal disease (IPD), is complicated by antimicrobial resistance. Widespread introduction in 2000 of heptavalent pneumococcal conjugate vaccine (PCV7) against serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F resulted in a decline in antimicrobial-nonsusceptible IPD in the United States, including in Massachusetts. However, development of antimicrobial resistance in serotypes not covered by PCV7 is a growing concern. In Massachusetts during 2001-2006, IPD surveillance identified an increased number of cases in children caused by pneumococcal serotypes (most notably 19A) not covered by PCV7 and an associated increase in antimicrobial resistance among these isolates. This report examines these trends and clinical characteristics of Massachusetts patients with antimicrobial-nonsusceptible, non-PCV7-type IPD. The findings indicated that, despite increases in incidence of antimicrobial-nonsusceptible IPD, overall rates of IPD remained stable during 2001-2006. In addition, persons with IPD caused by antimicrobial-nonsusceptible S. pneumoniae had clinical outcomes comparable to persons with IPD caused by antimicrobial-susceptible serotypes. Although PCV7 is effective in preventing IPD, these results confirm that antimicrobial resistance among serotypes not covered by PCV7 remains a concern.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  MMWR. Morbidity and mortality weekly report     Volume:  56     ISSN:  1545-861X     ISO Abbreviation:  MMWR Morb. Mortal. Wkly. Rep.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-19     Completed Date:  2007-10-22     Revised Date:  2008-03-27    
Medline Journal Info:
Nlm Unique ID:  7802429     Medline TA:  MMWR Morb Mortal Wkly Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1077-80     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Drug Resistance, Bacterial*
Massachusetts / epidemiology
Meningococcal Vaccines
Pneumococcal Infections / epidemiology*,  microbiology*
Pneumococcal Vaccines
Streptococcus pneumoniae / classification*,  drug effects*
Reg. No./Substance:
0/Meningococcal Vaccines; 0/Pneumococcal Vaccines; 0/heptavalent pneumococcal conjugate vaccine
Comment In:
Ann Emerg Med. 2008 Mar;51(3):312-5   [PMID:  18282525 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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