| Emergence of Qnr determinants in human Salmonella isolates in Taiwan. | |
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MedLine Citation:
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PMID: 18957397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to determine the prevalence and characteristics of qnr-carrying Salmonella isolates from humans in southern Taiwan. METHODS: A total of 446 Salmonella isolates collected between 2003 and 2006 were screened for qnrA, qnrB and qnrS by PCR experiments. Genetic structures of qnr were determined by PCR-based methods or direct sequencing of plasmid DNA. RESULTS: qnrB2 and qnrS1 were detected in two serovar Enteritidis isolates and two serovar Typhimurium isolates, respectively. One qnrS1-positive isolate was found to produce the CMY-2 AmpC enzyme. qnrS1 was identified on a 10 kb plasmid, which exhibited >99% nucleotide sequence identity with plasmid TPqnrS-1a reported from the UK. qnrB2 was found in a complex sul1-type class 1 integron on a >100 kb plasmid. CONCLUSIONS: This study demonstrated the occurrence of qnrB2 and qnrS1 in Salmonella for the first time in Taiwan and characterized their genetic structures. |
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Authors:
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Jiunn-Jong Wu; Wen-Chien Ko; Chien-Shun Chiou; Hung-Mo Chen; Li-Ron Wang; Jing-Jou Yan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-27 |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 62 ISSN: 1460-2091 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: England |
Other Details:
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Languages: eng Pagination: 1269-72 Citation Subset: IM |
Affiliation:
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Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University Medical College, Tainan 70101, Taiwan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/EU715253; EU715254 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Bacterial Proteins / genetics* DNA, Bacterial / chemistry, genetics Drug Resistance, Bacterial* Humans Molecular Sequence Data Plasmids Polymerase Chain Reaction / methods Quinolones / pharmacology* Salmonella Infections / epidemiology, microbiology* Salmonella enteritidis / drug effects*, genetics, isolation & purification Salmonella typhimurium / drug effects*, genetics, isolation & purification Sequence Analysis, DNA Sequence Homology, Nucleic Acid Taiwan / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Bacterial Proteins; 0/DNA, Bacterial; 0/Quinolones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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