Document Detail

Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review.
MedLine Citation:
PMID:  20455691     Owner:  NLM     Status:  MEDLINE    
Temozolomide chemotherapy has become part of the therapy used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Temozolomide frequently produces profound lymphopenia. We report 2 cases of cytomegalovirus disease that occurred in patients receiving temozolomide therapy and review 4 additional cases reported in the literature. Narrow monitoring with cytomegalovirus antigenemia assay should be considered for recommendation.
Yolanda Meije; Manuel Lizasoain; Ana García-Reyne; Pilar Martínez; Virginia Rodríguez; Francisco López-Medrano; Rafael San Juan; Antonio Lalueza; José María Aguado
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  50     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e73-6     Citation Subset:  IM    
Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Madrid, Spain.
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MeSH Terms
Antineoplastic Agents, Alkylating / adverse effects,  therapeutic use*
Central Nervous System Neoplasms / complications,  drug therapy
Cytomegalovirus Infections / complications*,  epidemiology
Dacarbazine / adverse effects,  analogs & derivatives*,  therapeutic use
Glioblastoma / complications,  drug therapy
Lymphoma, B-Cell / complications,  drug therapy
Middle Aged
Opportunistic Infections / complications
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 4342-03-4/Dacarbazine; 85622-93-1/temozolomide

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