| Embryotoxicity of zinc pyrithione, an antidandruff chemical, in fish. | |
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MedLine Citation:
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PMID: 10361029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early-life-stage toxicity tests of zinc pyrithione (Zpt) and commercial shampoos containing or not containing Zpt were performed on zebra fish and Japanese Medaka. The results showed that Zpt induced significant teratogenic effects on larvae of both species of fish. The two antidandruff shampoos containing Zpt induced the same teratogenic effects as Zpt. The calculated EC50 concentrations of Zpt for each of the shampoos were consistent with the EC50 for Zpt concentrate. Furthermore, 23 other shampoos not containing Zpt showed no teratogenic effects. These results strongly suggest that Zpt is the main factor in the antidandruff shampoos. |
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Authors:
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K Goka |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Environmental research Volume: 81 ISSN: 0013-9351 ISO Abbreviation: Environ. Res. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-07-07 Completed Date: 1999-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 81-3 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Academic Press. |
Affiliation:
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Regional Environment Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-0053, Japan. goka@nies.go.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ecosystem Fishes / embryology* Hair Preparations / toxicity Keratolytic Agents / toxicity* Larva / drug effects Organometallic Compounds / toxicity* Oryzias Pyridines / toxicity* Teratogens / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Hair Preparations; 0/Keratolytic Agents; 0/Organometallic Compounds; 0/Pyridines; 0/Teratogens; 13463-41-7/zinc pyrithione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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