Document Detail

Embryotoxicity and teratogenicity studies of an ayurvedic contraceptive--pippaliyadi vati.
MedLine Citation:
PMID:  11167037     Owner:  NLM     Status:  MEDLINE    
An ayurvedic contraceptive--pippaliyadi vati, containing equal parts of powdered seeds or fruit berries of Embelia ribes, fruit of Piper longum and borax powder was fed orally to two groups of pregnant rats: 2.5 times to one and five times to the other; the recommended dose for humans. The foetuses of mothers fed with pippaliyadi had low birth weights and were smaller in length. The mothers gained less weight during gestation. Developmental defects of soft tissues and skeletons were analyzed. There were instances of herniation of the intestines into the umbilical cord in foetuses of mothers who were administered pippaliyadi. The control and the gum acacia groups did not show such herniation.
M R Chaudhury; R Chandrasekaran; S Mishra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  74     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
Division of Toxicology, National Institute of Immunology, Aruna Asaf Ali Marg, 110067, New Delhi, India.
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MeSH Terms
Abnormalities, Drug-Induced / pathology
Birth Weight / drug effects
Bone and Bones / pathology
Contraceptives, Oral / toxicity*
Eating / drug effects
Embryo, Mammalian / pathology*
Fetus / pathology
Fruit / chemistry
Hernia, Inguinal / chemically induced,  congenital
Medicine, Ayurvedic*
Plant Extracts / toxicity*
Seeds / chemistry
Teratogens / toxicity*
Weight Gain / drug effects
Reg. No./Substance:
0/Contraceptives, Oral; 0/Plant Extracts; 0/Teratogens

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