Document Detail


Embryonic stem cell-derived trophoblast differentiation: a comparative review of the biology, function, and signaling mechanisms.
MedLine Citation:
PMID:  23291503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of the placenta is imperative for successful pregnancy establishment, yet the earliest differentiation events of the blastocyst-derived trophectoderm that forms the placenta remain difficult to study in humans. Human embryonic stem cells (hESC) display a unique ability to form trophoblast cells when induced to differentiate either by the addition of exogenous BMP4 or by the formation of cellular aggregates called embryoid bodies. While mouse trophoblast stem cells (TSC) have been isolated from blastocyst outgrowths, mouse ESC do not spontaneously differentiate into trophoblast cells. In this review, we focus on addressing the similarities and differences between mouse TSC differentiation and hESC-derived trophoblast differentiation. We discuss the functional and mechanistic diversity that is found in different species models. Of central importance are the unique signaling events that trigger downstream gene expression that create specific cellular fate decisions. We support the idea that we must understand the nuances that hESC differentiation models display so that investigators can choose the appropriate model system to fit experimental needs.
Authors:
M Giakoumopoulos; T G Golos
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-02-25
Journal Detail:
Title:  The Journal of endocrinology     Volume:  216     ISSN:  1479-6805     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-04-30     Revised Date:  2013-11-03    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  R33-45     Citation Subset:  IM    
Affiliation:
Wisconsin National Primate Research Center, Department of Obstetrics and Gynecology, University of Wisconsin-Madison, 1223 Capitol Court, Madison, Wisconsin 53715-1299, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
Embryonic Stem Cells / cytology*,  physiology
Female
Humans
Mice
Placenta / cytology,  physiology
Pregnancy
Signal Transduction / physiology*
Trophoblasts / cytology*,  physiology
Grant Support
ID/Acronym/Agency:
HD34215/HD/NICHD NIH HHS; HD38843/HD/NICHD NIH HHS; HD53925/HD/NICHD NIH HHS; P01 HD038843/HD/NICHD NIH HHS; P51 RR000167/RR/NCRR NIH HHS; P51OD011106/OD/NIH HHS; P51RR000167/RR/NCRR NIH HHS; R01 HD034215/HD/NICHD NIH HHS; R01 RR021876/RR/NCRR NIH HHS; R21 HD053925/HD/NICHD NIH HHS; RR020141-01/RR/NCRR NIH HHS; RR021876/RR/NCRR NIH HHS; RR15459-01/RR/NCRR NIH HHS; T32 HD041921/HD/NICHD NIH HHS
Comments/Corrections

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