Document Detail

Embryonic retinal gene expression in sonic-you mutant zebrafish.
MedLine Citation:
PMID:  12412019     Owner:  NLM     Status:  MEDLINE    
Hedgehog (Hh) signaling is required for proper eye development in vertebrates; known roles for Hh in the zebrafish include regulation of eye morphogenesis, ganglion cell neurogenesis, and photoreceptor differentiation. To gain insight into the mechanisms by which Hh signaling influences these developmental events, we have examined proliferation, cell death, and expression patterns of several retinal genes in the eyes of embryonic zebrafish lacking the sonic hedgehog gene. We find that features of the eye phenotype of the sonic-you (syu) mutant are consistent with multiple roles for the Hh signal during retinal development. Most interestingly, half of the mutant retinas failed to initiate cell differentiation and, instead, retained a neuroepithelial appearance. In the other half of the mutants, retinal cell differentiation was initiated, but not fully propagated. We also find that Hh signaling is important for retinal cell proliferation and retinal cell survival; together, these functions provide an explanation for progressive microphthalmia in the syu-/- mutant.
Deborah L Stenkamp; Ruth A Frey; Dianne E Mallory; Emily E Shupe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  225     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-05-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  344-50     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844-3051, USA.
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MeSH Terms
Cell Differentiation / physiology
Cell Division / physiology
Gene Expression Regulation, Developmental*
Hedgehog Proteins
Mutation / physiology
Retina / cytology,  embryology*,  physiology
Trans-Activators / genetics*
Grant Support
Reg. No./Substance:
0/Hedgehog Proteins; 0/Trans-Activators

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