Document Detail

Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway.
MedLine Citation:
PMID:  11241200     Owner:  NLM     Status:  MEDLINE    
TNF is a pleiotropic cytokine that modulates cell proliferation and apoptosis. The objective of the present study was to investigate the possible function(s) of the TNF/TNF-R1 signaling pathway in embryonic mouse submandibular salivary gland (SMG) morphogenesis. After characterizing in vivo mRNA and protein expression of various constituents of this pathway, we utilized in vitro experiments to investigate the phenotypic outcomes of enhanced and deficient ligand. The results of these experiments indicate that the TNF/TNF-R1 signal transduction pathway plays an important role in balancing cell proliferation and apoptosis during SMG duct and presumptive acini formation.
M Melnick; H Chen; Y Zhou; T Jaskoll
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Anatomical record     Volume:  262     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-05-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  United States    
Other Details:
Languages:  eng     Pagination:  318-30     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California 90089-0641, USA.
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MeSH Terms
Antigens, CD / genetics,  metabolism*
Cell Division
Culture Techniques
RNA, Messenger / genetics,  metabolism
Receptors, Tumor Necrosis Factor / genetics,  metabolism*
Receptors, Tumor Necrosis Factor, Type I
Signal Transduction
Submandibular Gland / cytology,  embryology*,  metabolism*
Thalidomide / pharmacology
Tumor Necrosis Factor-alpha / genetics,  metabolism*,  pharmacology
Grant Support
Reg. No./Substance:
0/Antigens, CD; 0/RNA, Messenger; 0/Receptors, Tumor Necrosis Factor; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Tumor Necrosis Factor-alpha; 50-35-1/Thalidomide

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