Document Detail

Embryonic mortality during the pre- and post-implantation periods of pregnancy in mature mice after superovulation.
MedLine Citation:
PMID:  1206643     Owner:  NLM     Status:  MEDLINE    
Sexually mature mice were stimulated to superovulate by giving exogenous gonadotrophins at known stages of the oestrous cycle. Untreated animals which ovulated spontaneously served as controls. The number of oocytes ovulated by each female was estimated from counts of the number of CL of pregnancy, and the incidence of embryonic mortality during the pre- and post-implantation stages of pregnancy was assessed from the number of zygotes recovered from the reproductive tract at 2-0 and 4-0 days post coitum and of conceptuses examined at 7-5 and 11-5 days post coitum. The mean number of oocytes ovulated by treated animals was 39-54, compared with 12-80 in controls: in mice which had superovulated, 44% of the ova were lost before implantation compared with about 10% in the controls. Further losses occurred about the time of implantation and at mid-pregnancy and thus the number of embryos classified as normal rarely exceeded the maximum found in controls. Death at mid-pregnancy seemed to be preceded by developmental retardation. The possibility that genetic and environmental factors play a role in embryonic loss after superovulation is discussed.
H M Beaumont; A F Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  45     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-04-02     Completed Date:  1976-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  437-48     Citation Subset:  IM    
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MeSH Terms
Cell Count
Corpus Luteum / analysis
Embryo Loss
Embryonic Development
Fetal Death*
Pregnancy, Animal*
Time Factors
Uterus / anatomy & histology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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