Document Detail

Embryonic karyotype of abortuses in relation to the number of previous miscarriages.
MedLine Citation:
PMID:  10685533     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the frequency of chromosomal abnormalities in products of conception from patients with recurrent miscarriages in relation to the number of previous miscarriages. DESIGN: Retrospective analysis. SETTING: Nagoya City University Medical Hospital. PATIENT(S): A total of 1,309 women with a history of 2-20 consecutive first-trimester abortions. INTERVENTION(S): Chromosomal analysis performed on products of conception with use of a standard G-banding technique. MAIN OUTCOME MEASURE(S): The frequencies of abnormal and normal embryonic karyotypes for each number of previous abortions were studied. The subsequent pregnancy outcome of patients whose previous miscarriages were karyotyped were studied along with the predictive value of karyotyping of previous miscarriages for subsequent miscarriages. RESULT(S): The miscarriage rate increased with the number of previous spontaneous abortions. The frequency of abnormal embryonic karyotypes significantly decreased and that of normal embryonic karyotypes significantly increased with the number of previous abortions. Among 71 patients whose embryonic karyotypes were normal, 44 aborted subsequently, and 23 of 60 patients whose embryonic karyotypes were abnormal aborted subsequently. Patients with a previous normal embryonic karyotype aborted more frequently than those with an abnormal karyotype. CONCLUSION(S): The frequency of normal embryonic karyotypes significantly increases with the number of previous abortions, and a normal karyotype in a previous pregnancy is a predictor of subsequent miscarriage.
M Ogasawara; K Aoki; S Okada; K Suzumori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  73     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-09     Completed Date:  2000-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan.
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MeSH Terms
Abortion, Habitual / genetics*,  immunology,  therapy
Antibodies / metabolism
Chromosome Aberrations*
Embryo, Mammalian / physiology*
Fetal Death / genetics*
Phospholipids / immunology
Retrospective Studies
Reg. No./Substance:
0/Antibodies; 0/Phospholipids

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