Document Detail


Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo.
MedLine Citation:
PMID:  1707784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have compared the expression of the genes encoding transforming growth factors beta 1, beta 2 and beta 3 during mouse embryogenesis from 9.5 to 16.5 days p.c. using in situ hybridisation to cellular RNAs. Each gene has a different expression pattern, which gives some indication of possible biological function in vivo. All three genes appear to be involved in chondroossification, though each is expressed in a different cell type. Transcripts of each gene are also present in embryonic epithelia. Epithelial expression of TGF beta 1, beta 2 and beta 3 RNA is associated with regions of active morphogenesis involving epithelial-mesenchymal interactions. In addition, widespread epithelial expression of TGF beta 2 RNA can be correlated with epithelial differentiation per se. The localisation of TGF beta 2 RNA in neuronal tissue might also be correlated with differentiation. Finally both TGF beta 1 and beta 2 transcripts are seen in regions actively undergoing cardiac septation and valve formation, suggesting some interaction of these growth factors in this developmental process.
Authors:
F A Millan; F Denhez; P Kondaiah; R J Akhurst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  111     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-05-17     Completed Date:  1991-05-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  131-43     Citation Subset:  IM    
Affiliation:
Duncan Guthrie Institute of Medical Genetics, University of Glasgow, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone and Bones / embryology,  physiology
Embryonic and Fetal Development / genetics*
Epithelium / embryology
Gene Expression / physiology*
Heart / embryology,  physiology
Lung / embryology,  physiology
Mice
Molecular Probes / chemical synthesis,  diagnostic use
Nervous System / embryology
Nervous System Physiological Phenomena
RNA / analysis*
Sense Organs / embryology,  physiology
Transforming Growth Factor beta / genetics*,  physiology
Chemical
Reg. No./Substance:
0/Molecular Probes; 0/Transforming Growth Factor beta; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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