| Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene. | |
| | |
MedLine Citation:
|
PMID: 18255354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The anion/cation symporter (ACS) family is a large subfamily of the major facilitator superfamily (MFS) of transporters. ACS family permeases are widely distributed in nature and transport either organic or inorganic anions in response to chemiosmotic cation gradients. The only protein in the ACS family to which a human disease has been linked, is sialin, the proton-driven lysosomal carrier for sialic acid. Genetic defects in sialin cause a lysosomal storage disease in humans. Here we have identified a group of conserved Drosophila ACS family genes related to sialin and studied their expression patterns throughout embryogenesis. Drosophila sialin-related genes are expressed in a wide variety of tissues. Expression is frequently observed throughout various parts of the intestinal tract, including Malpighian tubules and salivary glands. Additionally, some genes are expressed in vitellophages (yolk nuclei), nervous system, respiratory tract and a number of other embryonic tissues. These data will aid the establishment of a fruitfly model of human lysosomal storage disorders, the most common cause of neurodegeneration in childhood. |
| | |
Authors:
|
Bram Laridon; Patrick Callaerts; Koen Norga |
Related Documents
:
|
22073164 - Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatos... 10774724 - Atonal regulates neurite arborization but does not act as a proneural gene in the droso... 17636254 - Biosynthesis of truncated n-linked oligosaccharides results from non-orthologous hexosa... 20215474 - Hearing in drosophila requires tilb, a conserved protein associated with ciliary motility. 17328684 - Novel recombinant adenoviral vector that targets the interleukin-13 receptor alpha2 cha... 22384084 - Comparative gene expression profiling of p. falciparum malaria parasites exposed to thr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-23 |
Journal Detail:
|
Title: Gene expression patterns : GEP Volume: 8 ISSN: 1567-133X ISO Abbreviation: Gene Expr. Patterns Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-02-27 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101167473 Medline TA: Gene Expr Patterns Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 275-83 Citation Subset: IM |
Affiliation:
|
Laboratory of Developmental Genetics, V.I.B., Herestraat 49, Mailbox 602, B-3000 Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Anion Transport Proteins / classification, genetics, metabolism* Drosophila / embryology*, genetics, metabolism Drosophila Proteins / classification, genetics, metabolism* Embryo, Nonmammalian / metabolism Gene Expression Genes, Insect Humans In Situ Hybridization Molecular Sequence Data Organic Anion Transporters / chemistry RNA, Messenger / analysis Sequence Homology, Amino Acid Symporters / chemistry, classification, genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Anion Transport Proteins; 0/Drosophila Proteins; 0/Organic Anion Transporters; 0/RNA, Messenger; 0/Symporters; 0/sialic acid transport proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Performance characteristics of the suspected blood indicator feature in capsule endoscopy according ...
Next Document: The role of respiratory viruses in cystic fibrosis.