Document Detail

Embryonic development of fertilized rat oocytes induced to mature by an analogue of gonadotrophin-releasing hormone.
MedLine Citation:
PMID:  2119434     Owner:  NLM     Status:  MEDLINE    
A gonadotrophin-releasing hormone analogue (GnRHa) was administered to hypophysectomized immature rats. Postovulatory mature oocytes obtained under these conditions were exposed in vitro to a sperm suspension for fertilization. Developmental ability of the fertilized ova was studied by transfer of the 2-cell stage embryos to oviducts of foster mothers. The potential of oocytes, undergoing maturation in response to GnRHa, to develop into 2-cell embryos was similar to that of oocytes stimulated by hCG (76.4% and 83.1% respectively). The 2-cell stage embryos obtained from such oocytes were equally able to implant in the uteri of foster mothers (25.7% and 21.2% respectively) and subsequently develop into live embryos (15.3% and 15.2%, respectively, at Day 20 of pregnancy).
R Shalgi; N Dekel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  89     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-24     Completed Date:  1990-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  681-7     Citation Subset:  IM    
Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
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MeSH Terms
Buserelin / pharmacology*
Embryo Transfer
Embryo, Mammalian / physiology*
Fertilization in Vitro
Oocytes / drug effects,  physiology*
Rats, Inbred Strains
Reg. No./Substance:

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