Document Detail


Embryonic delay in growth and development related to confined placental trisomy 16 mosaicism, diagnosed by I-Space Virtual Reality.
MedLine Citation:
PMID:  18793769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To demonstrate the use of a novel three-dimensional (3D) virtual reality (VR) system in the visualization of first trimester growth and development in a case of confined placental trisomy 16 mosaicism (CPM+16). DESIGN: Case report. SETTING: Prospective study on first trimester growth using a 3D VR system. PATIENT(S): A 34-year-old gravida 1, para 0 was seen weekly in the first trimester for 3D ultrasound examinations. INTERVENTION(S): Chorionic villus sampling was performed because of an enlarged nuchal translucency (NT) measurement and low pregnancy-associated plasma protein-A levels, followed by amniocentesis. RESULT(S): Amniocentesis revealed a CPM+16. On two-dimensional (2D) and 3D ultrasound no structural anomalies were found with normal fetal Dopplers. Growth remained below the 2.3 percentile. At 37 weeks, a female child of 2010 g (<2.5 percentile) was born. After birth, growth climbed to the 50th percentile in the first 2 months. CONCLUSION(S): The I-Space VR system provided information about phenotypes not obtainable by standard 2D ultrasound. In this case, the delay in growth and development could be observed very early in pregnancy. Since first trimester screening programs are still improving and becoming even more important, systems such as the I-Space open a new era for in vivo studies on the physiologic and pathologic processes involved in embryogenesis.
Authors:
Christine M Verwoerd-Dikkeboom; Peter N A C M van Heesch; Anton H J Koning; Robert-Jan H Galjaard; Niek Exalto; Eric A P Steegers
Related Documents :
17582229 - Intrathoracic fluid may be a normal finding at around 8 gestational weeks.
19797009 - Prenatal sonographic features of fetuses in trisomy 13 pregnancies (ii).
8413959 - Pregnancy and delivery in charcot-marie-tooth disease type 1.
12627429 - First-trimester nuchal translucency measurement and echocardiography at 16 to 18 weeks ...
17267839 - Nuchal translucency and the risk of congenital heart disease.
18618989 - Prenatal diagnosis of trisomy 21: registration results from a single genetic center.
15062449 - Ultrasound-guided procedures for prenatal diagnosis and therapy.
17766509 - The mechanisms of low birth weight in infants of mothers with homozygous sickle cell di...
21087419 - Core body temperature and the thermoneutral zone: a longitudinal study of normal human ...
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-09-14
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2008-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2017.e19-22     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands. c.verwoerd@erasmusmc.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amniocentesis
Chorionic Villi Sampling
Chromosomes, Human, Pair 16*
Female
Fetal Growth Retardation / genetics,  metabolism,  ultrasonography*
Humans
Image Interpretation, Computer-Assisted*
Imaging, Three-Dimensional
Infant, Low Birth Weight
Infant, Newborn
Live Birth
Mosaicism*
Pregnancy
Pregnancy Trimester, Third
Pregnancy-Associated Plasma Protein-A / analysis
Trisomy*
Ultrasonography, Prenatal*
User-Computer Interface*
Chemical
Reg. No./Substance:
EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Laser zona thinning in women aged &lt;or=37 years: a randomized study.
Next Document:  Blepharophimosis-ptosis-epicanthus inversus syndrome and hypergonadotropic hypogonadism.